Hepatic Defenses Against Toxicity: Liver Regeneration and Tissue Repair

Apte, Udayan; Bhushan, Bharat; Dadhania, Vivekkumar P.

doi:10.1016/b978-0-12-801238-3.64918-8

Cited by 1 publication

(4 citation statements)

References 209 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Over time, we have gained good insights into the role of ER stress response in PH and drug-induced liver toxicity. 109 We believe that in the future, an even clearer picture of ER stress in various other liver diseases will emerge. 158 ER plays a central role in cellular homeostasis and different environmental conditions like toxicant exposure and physical injury have been associated with distorting cellular homeostasis.…”

Section: Discussionmentioning

confidence: 96%

Section: Accepted Manuscriptmentioning

confidence: 99%

“…Liver regeneration is a complex process relying on internal and external signals that control the nature and extent of regeneration. 109,124 The purpose of liver regeneration is to retain the lost stability of liver functioning which is critical for maintaining physiological homeostasis. Interestingly, under conditions of excessive liver parenchymal cell damage, nonparenchymal cells are seen to undergo active regeneration and transdifferentiate into hepatocytes through genome-wide alterations (epigenetic and transcriptomic) and signaling pathway rewiring.…”

Section: Liver Injury and Regeneration Dynamics After Partial Hepatec...mentioning

confidence: 99%

“…106 107 These newly formed cells make up for the lost liver tissue and restore normal liver function. 71 108 109 Multiple studies discussed in this section highlight the role of ER stress response signaling in liver regeneration after chemical-induced liver injury.…”

Section: The Role Of Er Stress During Liver Pathogenesis and Regenera...mentioning

confidence: 99%

See 3 more Smart Citations

The Role of Endoplasmic Reticulum Stress Response in Liver Regeneration

Deshmukh

Apte

2023

Semin Liver Dis

View full text Add to dashboard Cite

Exposure to hepatotoxic chemicals is involved in liver disease-related morbidity and mortality worldwide. The liver responds to damage by triggering compensatory hepatic regeneration. Physical agent or chemical-induced liver damage disrupts hepatocyte proteostasis, including endoplasmic reticulum (ER) homeostasis. Post liver injury ER experiences a homeostatic imbalance, followed by active ER stress response signaling. Activated ER stress response causes selective upregulation of stress response genes and downregulation of many hepatocyte genes. Acetaminophen overdose, CCl4, acute and chronic alcohol exposure, and physical injury activates the ER stress response, but details about the cellular consequences of the ER stress response on liver regeneration remain unclear. The current data indicate that inhibiting the ER stress response after partial hepatectomy-induced liver damage promotes liver regeneration, whereas inhibiting the ER stress response after chemical-induced hepatotoxicity impairs liver regeneration. This review summarizes key findings and emphasizes the knowledge gaps in role of ER stress in injury and regeneration.

show abstract

Section: Discussionmentioning

confidence: 96%

Section: Accepted Manuscriptmentioning

confidence: 99%

Section: Liver Injury and Regeneration Dynamics After Partial Hepatec...mentioning

confidence: 99%