Hepatic danger signaling triggers TREM2
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macrophage induction and drives steatohepatitis via MS4A7-dependent inflammasome activation
Linkang Zhou,
Xiaoxue Qiu,
Ziyi Meng
et al.
Abstract:Metabolic dysfunction–associated steatohepatitis (MASH), formerly known as nonalcoholic steatohepatitis (NASH), is an advanced stage of metabolic fatty liver disease. The pathogenic mechanisms of MASH center on hepatocyte injury and the ensuing immune response within the liver microenvironment. Recent work has implicated TREM2
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macrophages in various disease conditions, and substantial induction of TREM2
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NASH-associated macrophages (NAMs) serves as a hallmark … Show more
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