Hepatic Damage in Experimental and Clinical Paragonimiasis

Computed tomography findings in disseminated paragonimiasis

“…In this case CT also demonstrated cystic masses in both the chest wall overlying the liver and the peritoneal cavity. Small focal lesions were shown in the liver which on biopsy were found to represent small eosinophilic abscesses, similar to those reported by Hu et al (1982). Extensive adhesions, fibrosis, and nodules on the omentum were found at peritoneoscopy indicating that the parasites had migrated through and caused damage to several organs within the peritoneal cavity.…”

Characteristic MR and CT imaging findings of hepatobiliary paragonimiasis and their pathologic correlations

“…Granulomatous inflammation and/or granulomas around the abscesses, as observed on the microscopic examination, were responsible for the separate irregular rim or circular enhancement of the lesions on contrast CT and MR images, which is similar to the findings reported by Hu et al (1,9,10). In invasive paragonimiasis, the parasites migrate through the hepatic parenchyma, invade the bile duct and cause chronic cholangitis.…”

Imaging Findings of Hepatic Paragonimiasis: A Case Report

“…But in an experimental study reported by Hu et al (12), the frequency of hepatic involvement was higher than expected. They fed metacercariae of P. westermani to dogs and found adult worms in the liver 3 to 49 days after ingestion.…”

“…The CT and MR imaging features of clustered, rim-enhancing cysts are reflections of eosinophilic abscesses containing necrotic debris and Paragonimus eggs histologically (2). Hepatic capsular enhancement and wedge-shaped perilesional enhancement at CT scan can be explained due to inflammatory changes, according to the previously reported microscopic examination in which acute inflammation of the hepatic capsule and adjacent parenchyma were described to be seen adjacent to eosinophilic abscess (12). The peripheral location of the lesion reflects that the worms invade into the liver through the capsule and reside around the capsule rather than in the deep portion, as demonstrated by experimental studies in which metacercariae were present near to the surface in hepatic paragonimiasis (12, 15).…”