Hepatic CYP3A expression and activity in low birth weight developing female rats

Zhu, Zhiwei; Ni, Shuang; Wang, Xiumin; Wang, Jue; Zeng, Su; Zhao, Zhiyuan

doi:10.1007/s12519-013-0429-x

Cited by 4 publications

(1 citation statement)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In neonates, this effect was accompanied by a higher Cyp2a5 gene expression, which was correlated with higher DNA methylation. Besides, there is also evidence that hepatic drug metabolism may be altered in low birth weight rats, with reports of both increased and decreased P450 enzymes expression [107][108][109] . Despite the fact that our data failed to indicate pharmacokinetic interactions between SMK and ETOH by the end of exposure, considering that there is a positive association between nicotine metabolism and nicotine addiction 110,111 , whether there are differences in nicotine pharmacokinetics between SMK and SMK þ ETOH mice during adolescence and adulthood is worth further investigation.…”

Section: Body Mass Cotinine and Ethanol Levelsmentioning

confidence: 99%

Sex- and age-dependent differences in nicotine susceptibility evoked by developmental exposure to tobacco smoke and/or ethanol in mice

Nunes‐Freitas

Manhães

Dutra-Tavares

et al. 2020

J Dev Orig Health Dis

View full text Add to dashboard Cite

Either tobacco smoking or alcohol consumption during pregnancy sex-selectively increases susceptibility to drugs of abuse later in life. Considering that pregnant smoking women are frequently intermittent consumers of alcoholic beverages, here, we investigated whether a short-term ethanol exposure restricted to the brain growth spurt period when combined with chronic developmental exposure to tobacco smoke aggravates susceptibility to nicotine in adolescent and adult mice. Swiss male and female mice were exposed to tobacco smoke (SMK; research cigarettes 3R4F, whole-body exposure, 8 h/daily) or ambient air during the gestational period and until the tenth postnatal day (PN). Ethanol (ETOH, 2 g/Kg, 25%, i.p.) or saline was injected in the pups every other day from PN2 to PN10. There were no significant differences in cotinine (nicotine metabolite) and ethanol serum levels among SMK, ETOH and SMK + ETOH groups. During adolescence (PN30) and adulthood (PN90), nicotine (NIC, 0.5 mg/Kg) susceptibility was evaluated in the conditioned place preference and open field tests. NIC impact was more evident in females: SMK, ETOH and SMK + ETOH adolescent females were equally more susceptible to nicotine-induced place preference than control animals. At adulthood, SMK and SMK + ETOH adult females exhibited a nicotine-evoked hyperlocomotor profile in the open field, with a stronger effect in the SMK + ETOH group. Our results indicate that ethanol exposure during the brain growth spurt, when combined to developmental exposure to tobacco smoke, increases nicotine susceptibility with stronger effects in adult females. This result represents a worsened outcome from the early developmental dual exposure and may predispose nicotine use/abuse later in life.

show abstract

Section: Body Mass Cotinine and Ethanol Levelsmentioning

confidence: 99%

Sex- and age-dependent differences in nicotine susceptibility evoked by developmental exposure to tobacco smoke and/or ethanol in mice

Nunes‐Freitas

Manhães

Dutra-Tavares

et al. 2020

J Dev Orig Health Dis

View full text Add to dashboard Cite

show abstract

A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats

Lou

Wang

et al. 2016

World J Pediatr

View full text Add to dashboard Cite

show abstract

Constitutive expression of cytochrome P450 in foetal and adult porcine livers—Effects of body weight

2016

View full text Add to dashboard Cite

Hepatic CYP3A expression and activity in low birth weight developing female rats

Abstract: We found the effect of LBW on CYP3A activity was most prominent during the early days of life in rats. Investigators and clinicians should consider the effect of LBW on CYP3A in both pharmacokinetic study design and data interpretation, when prescribing drugs to LBW infants.

Cited by 4 publications

References 25 publications

Sex- and age-dependent differences in nicotine susceptibility evoked by developmental exposure to tobacco smoke and/or ethanol in mice

Sex- and age-dependent differences in nicotine susceptibility evoked by developmental exposure to tobacco smoke and/or ethanol in mice

A high-fat high-energy diet influences hepatic CYP3A expression and activity in low-birth-weight developing female rats

Constitutive expression of cytochrome P450 in foetal and adult porcine livers—Effects of body weight

Contact Info

Product

Resources

About