1965
DOI: 10.1136/bmj.1.5428.168
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Hepatic Coma Due to Liver Metastases

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Cited by 12 publications
(2 citation statements)
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“…Symptoms can range from mild alterations in consciousness or behavior to coma (2). In cancer patients, hepatic encephalopathy is usually the result of abnormality of the portal venous system (3) such as thrombosis (4) or hypertension (5) causing portosystemic shunting, or massive hepatic tumor burden causing global hepatocellular insufficiency (6, 7). These changes may result in the inability of the liver to metabolize many substances including ammonia (8).…”
Section: Introductionmentioning
confidence: 99%
“…Symptoms can range from mild alterations in consciousness or behavior to coma (2). In cancer patients, hepatic encephalopathy is usually the result of abnormality of the portal venous system (3) such as thrombosis (4) or hypertension (5) causing portosystemic shunting, or massive hepatic tumor burden causing global hepatocellular insufficiency (6, 7). These changes may result in the inability of the liver to metabolize many substances including ammonia (8).…”
Section: Introductionmentioning
confidence: 99%
“…Abnormal liver texture was noted on imaging in less than half the cases described by Rowbotham et al . Massive increases in aminotransferases (up to 100-fold elevated) can occur with malignant infiltration3 4 5 and would help to exclude acute alcoholic hepatitis, which may occasionally be misdiagnosed in this setting 6. Lactic acidosis and a disproportionately raised lactate dehydrogenase are suggestive of haematological malignancy 7.…”
mentioning
confidence: 99%