Hepatic Cell Necrosis in the Newborn

Shiraki, Kazuo

doi:10.1001/archpedi.1970.02100050397003

Cited by 23 publications

(3 citation statements)

References 16 publications

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“…Shiraki (1970), in a parallel study of 146 infants dying from birth to 7 days of age, noted hepatic necrosis in 24-5% and fatty changes in a further 14-3% of cases. He concluded that hypoplastic left heart complex and coarctation of the aorta were more frequently associated with hepatic necrosis than with any other type of congenital heart disease.…”

Section: Discussionmentioning

confidence: 93%

Hypoxia and asymmetrical fibrosis of the liver in children

Ghosh¹,

Emery²

1973

Gut

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SUMMARY The liver in children contains a greater amount of connective tissue in relation to parenchymal tissue than in adults and there is often more in the left than in the right lobe. Livers from 150 children who died between birth and 12 years of age, under different circumstances, were studied.The findings suggested that hypoxia was an important factor leading to increase in fibrous tissue in children's livers. Children who had cyanosis at birth and prolonged hypoxia associated with pathological conditions showed the highest ratio of connective tissue to liver parenchyma. The predominant non-hepatic lesions found were cyanotic congenital heart disease, coarctation of the aorta, acute respiratory distress, congenital malformation of the central nervous system, and shock after abdominal surgery.The liver consists of two physiological lobes which differ from the anatomical demarcation (Cantlie, 1897(Cantlie, -1898Mall, 1906). Asymmetrical changes in two lobes of the liver have been noted in infancy (Emery, 1955) and foetal life (Gruenwald, 1949;Emery, 1963) and have been related to the differing vascular pattern in intrauterine and in postnatal periods.The connective tissue content of children's livers is significantly higher at all times and more marked in the left than in the right lobe (Ghosh and Emery, 1970), and it was suggested that the quantity of fibrous tissue might be related to the degree and duration of shock and hypoxia in the neonatal period and childhood. The present study was carried out in order to assess the possible effect of hypoxia on the production of hepatic fibrosis. Material and MethodsIt is customary in this hospital to take controlled sections from the left and right physiological lobes of the liver and the paired sections are filed serially.The slides are stained by Masson's trichrome. Three thousand five hundred paired sections were drawn out randomly, surveyed, and sections were selected which showed an obvious increase of connective tissue content and a distinct difference between the left and right lobes. Controls were selected by taking

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Section: Discussionmentioning

confidence: 93%

Hypoxia and asymmetrical fibrosis of the liver in children

Ghosh¹,

Emery²

1973

Gut

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“…Breast feeding was established, but tachypnoea developed on day 3. Jaundice was noted by the attending midwife on day 4 and was felt to be physiological. It did not improve, however, and serum bilirubin concentration on day 7 was 615 ,umolVl (565 p.molIl unconjugated).…”

mentioning

confidence: 99%

Severe unconjugated hyperbilirubinaemia with infradiaphragmatic total anomalous pulmonary venous connection.

Burch

Dyamenahalli

Sullivan

1993

Archives of Disease in Childhood

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“…Die von der UAB und den mit ihr kombinierten Herzfehlern hervorgerufenen komplexen hämodynamischen Veränderungen führen zu einer Letalität von 80% im ersten Lebensmonat(1, 2). Beim "hypoplastischen linken Herz-Syndrom" wurden zusätzlich zu der myokardialen Ischämie (41) schwere Lebernekrosen mit Hypoglykämie und hämorrhagischer Diathese beschrieben(42,43).Ein großer Ductus arteriosus persistens scheint einen negativen Einfluß auf die Prognose zu haben, weil die Entwicklung der Kollateralarterien dann nicht stimuliert wird(16). Da der rechte Ventrikel über den Ductus arteriosus persistens die Aorta descendens versorgt ("systemic right ventricle"), führt ein plötzlicher Verschluß des Ductus arteriosus zu einer konservativ nicht beeinflußbaren Herzinsuffizienz.…”

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Unterbrechung des Aortenbogens mit Fallot'scher Tetralogie

Manouguian¹,

Bjørnstad²,

Rastan³

1975

Thorac cardiovasc Surg

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In a ten year old girl, a combination of interruption of the aortic arch (IAA) and tetralogy of Fallot was corrected simultaneously using cardiopulmonary bypass. The interruption was bypassed by implantation of the proximal end of the left subclavian artery into the ascending aorta. The simultaneous correction of both malformations was possible by a left anterolateral transsternal thoracotomy. The success of this operation was confirmed by cardiac cathetherization and angiography. As far as we know this the first report of a successful simultaneous correction of this unusual combination of cardiac malformations.

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Hepatic Cell Necrosis in the Newborn

Cited by 23 publications

References 16 publications

Hypoxia and asymmetrical fibrosis of the liver in children

Hypoxia and asymmetrical fibrosis of the liver in children

Severe unconjugated hyperbilirubinaemia with infradiaphragmatic total anomalous pulmonary venous connection.

Unterbrechung des Aortenbogens mit Fallot'scher Tetralogie

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