Hepatic cavernous hemangioma: appearance on T2-weighted fast spin-echo MR imaging with and without fat suppression.

Soyer, Philippe; Dufresne, Anne-Charlotte; Somveille, Edith; Scherrer, Antoine

doi:10.2214/ajr.168.2.9016227

Cited by 37 publications

(18 citation statements)

References 23 publications

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“…Thus, 2 main ndings, already known as useful features in conventional dynamic CT or MR imaging, can be used to distinguish hemangioma from metastasis when gadoxetic acid-enhanced MR imaging is used-ringlike enhancement on arterial phase images, which is observed more frequently in metastasis than hemangioma 54 (Fig. 3a), and very high signal intensity on T 2 -weighted images, 55 which is more common in hemangioma than metastasis (Fig. 3b).…”

Section: Lesion Characterization Hemangioma Versus Hepatic Metastasismentioning

confidence: 99%

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Ichikawa

Araki

2013

magn reson med sci

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Since its launch onto the world medical market, gadoxetic acid has received a great deal of attention from a diverse group of researchers, including gastroenterologists, hepatologists, and abdominal radiologists. Gadoxetic acid in liver magnetic resonance (MR) imaging might be considered to have excellent utility. However, several issues remain that radiologists should keep in mind when utilizing this product. We compiled this review to introduce gadoxetic acid, describe how it should be used, highlight the situations in which it is most and least reliable, and suggest potential avenues for future research.

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Section: Lesion Characterization Hemangioma Versus Hepatic Metastasismentioning

confidence: 99%

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Ichikawa

Araki

2013

magn reson med sci

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“…Medium-sized (1-5 cm) hemangiomas, the most common, show peripheral nodular enhancement, with progressive centripetal enhancement and fill-in on equilibrium phase images (Type II) (Fig. 1b) [28,29]. Larger lesions or so called giant hemangiomas (>5 cm), also show a peripheral nodular enhancement and centripetal fill-in, but can have a 3 Fig.…”

Section: Hemangiomamentioning

confidence: 99%

Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions

et al. 2008

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Screening of the liver for hepatic lesion detection and characterization is usually performed with either ultrasound or CT. However, both techniques are suboptimal for liver lesion characterization and magnetic resonance (MR) imaging has emerged as the preferred radiological investigation. In addition to unenhanced MR imaging techniques, contrast-enhanced MR imaging can demonstrate tissue-specific physiological information, thereby facilitating liver lesion characterization. Currently, the classes of contrast agents available for MR imaging of the liver include non-tissue-specific extracellular gadolinium chelates and tissue-specific hepatobiliary or reticuloendothelial agents. In this review, we describe the MR features of the more common focal hepatic lesions, as well as appropriate imaging protocols. A special emphasis is placed on the clinical use of non-specific and liver-specific contrast agents for differentiation of focal liver lesions. This may aid in the accurate diagnostic workup of patients in order to avoid invasive procedures, such as biopsy, for lesion characterization. A diagnostic strategy that considers the clinical situation is also presented.

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“…Diagnosis of large cavernous haemangiomas is generally straightforward and can be made through the combination of T2-weighted imaging, pre-contrast and dynamic post-contrast T1-weighted imaging and diffusion-weighted imaging. However, the enhancement pattern of small haemangiomas may be challenging to characterize and large cavernous haemangiomas may display atypical features, making the diagnosis uncertain [15, 16]. Given the high prevalence of haemangiomas, the ability to diagnose them with confidence is an important component of metastatic staging in the liver [10, 11, 17].…”

Section: Introductionmentioning

confidence: 99%

Combined gadoxetic acid and gadofosveset enhanced liver MRI for detection and characterization of liver metastases

et al. 2016

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Purpose To compare gadoxetic acid alone and combined gadoxetic acid/gadofosveset trisodium-enhanced liver MRI for detection of metastases and differentiation of metastases from haemangiomas. Methods Ninety-one patients underwent gadoxetic acid-enhanced liver MRI before and after additional injection of gadofosveset. First, two readers retrospectively identified metastases on gadoxetic acid alone enhanced delayed hepatobiliary phase T1-weighted images together with all other MR images (dynamic images, T2-weighted images, diffusion-weighted images). Second, readers assessed additional T1-weighted images obtained after administration of gadofosveset trisodium. For both interpretations, readers rated lesion conspicuity and confidence in differentiating metastases from haemangiomas. Results were compared using alternative free-response receiver-operating characteristic (AFROC) and conventional ROC methods. Histology and follow-up served as reference standard. Results There were 145 metastases and 16 haemangiomas. Both readers detected more metastases using combined gadoxetic acid/gadofosveset (reader 1 =130; reader 2=124) compared to gadoxetic acid alone (reader 1 = 104; reader 2=103). Sensitivity of combined gadoxetic acid/gadofosveset (reader 1 = 90 %; reader 2 = 86 %) was higher than that of gadoxetic acid alone (reader 1=72 %; reader 2 = 71 %, both P<0.01). AFROC-AUC was higher for the combined technique (0.92 vs. 0.86, P< 0.001). Sensitivity for correct differentiation of metastases from haemangiomas was higher for the combined technique (reader 1 =98 %; reader 2 = 99 % vs. reader 1 = 86 %; reader 2 = 91 %, both P<0.01). ROC-AUC was significantly higher for the combined technique (reader 1 =1.00; reader 2=1.00 vs. reader 1 =0.87; reader 2=0.92, both P<0.01). Conclusion Combined gadoxetic acid/gadofosveset-enhanced MRI improves detection and characterization of liver metastases compared to gadoxetic acid alone.

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Hepatic cavernous hemangioma: appearance on T2-weighted fast spin-echo MR imaging with and without fat suppression.

Cited by 37 publications

References 23 publications

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Rules, Roles, and Room for Discussion in Gadoxetic Acid-enhanced Magnetic Resonance Liver Imaging: Current Knowledge and Future Challenges

Clinical value of MRI liver-specific contrast agents: a tailored examination for a confident non-invasive diagnosis of focal liver lesions

Combined gadoxetic acid and gadofosveset enhanced liver MRI for detection and characterization of liver metastases

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