Hepatic Assistance After Subtotal or Total Hepatectomy in the Dog

Joyeux, H; Joyeux, A; Raoux, P; Brissac, C; Yakoun, M; Blanc, F.; Fourcade, J; Solassol, C

doi:10.1097/00002480-197700230-00186

Cited by 9 publications

(6 citation statements)

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“…However, such animals seldom show features of hepatic encephalopathy, but rather of respiratory failure (26). Furthermore, problems encountered with partial hepatectomy models are common and universal to rabbit, dog and pig (27)(28)(29)(30). Low reproducibility and lack of the clinical pattern seen in man raises serious questions regarding massive liver resection models and their relevance in pathophysiologi c studies in acute liver failure (1).…”

Section: Biochemical Alterationsmentioning

confidence: 99%

An Experimental Large Animal Model for the Assessment of Bioartificial Liver Support Systems in Fulminant Hepatic Failure

Ytrebø¹,

Nedredal²,

Langbakk³

2002

Scandinavian Journal of Gastroenterology

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Section: Biochemical Alterationsmentioning

confidence: 99%

An Experimental Large Animal Model for the Assessment of Bioartificial Liver Support Systems in Fulminant Hepatic Failure

Ytrebø¹,

Nedredal²,

Langbakk³

2002

Scandinavian Journal of Gastroenterology

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“…Problems encountered with these models are common and universal to rabbit, dog and pig ( Pappas et al . 1970 ; Joyeux et al . 1977 ; Fick et al .…”

Section: Surgical Modelsmentioning

confidence: 99%

Animal models of acute hepatic failure

Rahman

Hodgson

2000

Int J Experimental Path

147

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The understanding and treatment of acute hepatic failure has developed rapidly over the last 40 years reducing morbidity and mortality from this syndrome. Progress has been made by the study of animal models that reflect the clinical, biochemical and histological pattern of the syndrome seen in man. This is of increasing importance with the use of therapeutic intervention, liver transplantation and the use of extra-corporeal liver support devices. This review examines and critically appraises the various approaches to the study of acute hepatic failure in animal models, including both surgical and pharmacological approaches.

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“…is not yet well understood, and so, to clarify it, numerous animal models have been established [1][2][3][4][5][6][7][8][9][10][11][12]. Previously, we clearly demonstrated that 90%-hepatectomy is a safety limit for rat hepatectomy.…”

Section: Introductionmentioning

confidence: 99%