Hepatic arterial infusion plus systemic chemotherapy as third-line or later treatment in colorectal liver metastases

Abstract

HAI combined with SCT treatment can improve overall survival compared with SCT alone in highly advanced CLM refractory to intravenous chemotherapy.

Hepatic Artery Infusion Pump Combined With Systemic Chemotherapy for Patients With Liver Metastases From Breast Carcinoma

“…HAI chemotherapy has been widely accepted in the treatment of colorectal cancer liver metastasis patients. 11 - 13 In addition, HAI chemotherapy has also been suggested to be helpful for patients with NPC liver metastasis, but a few patients had extrahepatic progression during the trial treatment. 15 In this study, we administered HAI gemcitabine plus FUDR combined with systemic chemotherapy for 19 patients with BCLM.…”

“…The infusion catheter and injection port (Celsite, B. Braun, Chasseneuil, France) were implanted as previously described. 12 , 15 , 16 The main steps of this procedure include the following: (a) The anatomy of the hepatic artery and indication for HAI therapy were evaluated by computed tomography angiography before the operation; (b) the Seldinger technique was used to obtain access to the right femoral artery under the guide of digital subtract angiography (DSA); (c) angiography of the celiac trunk and superior mesenteric artery was performed to reveal the anatomy of the hepatic artery; (d) the gastro-duodenal artery (GDA), right gastric artery, and, if necessary, left gastric artery or dorsal pancreatic artery were embolized using metallic coils (Tornade, Cook, Bloomington, IL, USA) to prevent gastrointestinal mucosa injury caused by chemotherapy drugs; (e) the infusion catheter with side holes was placed into the GDA using the same coils as mentioned above or was inserted into the peripheral branch of the hepatic artery, and the position of the side hole was sited at the common hepatic artery. Therefore, the chemotherapeutic agents infused the entire liver from the side hole; (f) the proximal end of the infusion catheter was connected to an injection port, and the device was implanted into a subcutaneous pocket in the right inner thigh.…”

“…Previous studies have suggested that the combination of a hepatic arterial infusion pump and systematic chemotherapy was helpful for patients with colorectal liver metastases (CRLM) to achieve a high local response and prolong survival. 11 - 14 Moreover, it was reported that HAI gemcitabine and FUDR were effective in prolonging survival time and improving the DCR of intrahepatic lesions for NPC patients with liver metastasis and were connected with a relatively low rate of toxicity. 15 The purpose of this study was to explore the benefits and risks of HAI chemotherapy in patients with breast cancer liver metastasis.…”

<p>Hepatic Arterial Infusion Combined with Systemic Chemotherapy for Patients with Extensive Liver Metastases from Gastric Cancer</p>

“…The catheter/port system (Celsite, B. Braun, Chasseneuil, France) was implanted by fixed catheter tip method as described previously. 7 Hepatic arterial angiography prior to port-catheter implantation was performed to assess arterial supply to extrahepatic adjacent organs. The gastroduodenal artery, right gastric artery and left gastric artery were embolized with metallic coils (Tornade, Cook, Bloomington, IL, USA) to prevent the gastrointestinal mucosa injury caused by chemotherapy drugs.…”