Hepatic arterial infusion chemotherapy using percutaneous catheter placement with an implantable port: Assessment of factors affecting patency of the hepatic artery

Seki, Hiroshi; Kimura, Masao; Yoshimura, Norihiko; Yamamoto, Satoshi; Ozaki, Toshirou; Sakai, Kunio

doi:10.1016/s0009-9260(99)91155-8

Cited by 63 publications

(27 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…On the other hand, there are several problems associated with HAIC, as follows: (1) skill is required to appropriately insert the catheter; (2) catheter placement is very invasive for patients; (3) infection may occur via the catheter system, and (4) the catheter system or hepatic artery may become obstructed [17]. In this study, 1 patient experienced obstruction of the hepatic artery.…”

Section: Discussionmentioning

confidence: 85%

Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

Ueshima¹,

Kudo²,

Takita³

et al. 2010

Oncology

View full text Add to dashboard Cite

Background: Although hepatic arterial infusion chemotherapy (HAIC) using low-dose 5-fluorouracil (5-FU) and cisplatin (low-dose FP) is commonly used for advanced hepatocellular carcinoma (HCC) with vascular invasion in Japan, few reports have investigated the efficacy and safety of this approach. We investigated the efficacy and toxicity of HAIC using low-dose FP for patients with advanced HCC as a phase II trial. Methods: Low-dose FP consisted of a continuous arterial infusion of 5-FU (250–500 mg/day, 5 days/week, for the first 2 weeks) and cisplatin (10 mg/day, 5 days/week, for the first 2 weeks). Then, 5-FU (1,000 mg/body for 5 h) and cisplatin (10 mg/body) were administered once weekly. Results: In these patients treated with low-dose FP, the response rate was 38.5%, the median time to progression was 4.1 months (95% CI 2.1–6.1 months) and the median survival time was 15.9 months (95% CI 9.8–22.0 months). The most frequent adverse events were myelosuppression such as neutropenia or thrombocytopenia. Conclusions: HAIC using low-dose FP is an effective treatment option for locally advanced HCC. However, it is not well tolerated hematologically because of potent pancytopenia and poor hepatic reserve. Therefore, this regimen should be performed carefully with regular monitoring of hematological function.

show abstract

Section: Discussionmentioning

confidence: 85%

Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

Ueshima¹,

Kudo²,

Takita³

et al. 2010

Oncology

View full text Add to dashboard Cite

show abstract

“…Although a few reports of indwelling port-catheter systems using other interventional procedures showed a lower frequency of hepatic arterial occlusion [10,16,17], the numbers of subjects in these reports were much smaller than in that of Arai et al [12]. According to Seki et al [11], hepatic artery patency was statistically higher in the group in which port-catheter systems were implanted by Arai's method than in that in which the catheter tip was placed in the proper or common hepatic artery without fixation of the catheter tip. This result leads us to speculate that one main cause of hepatic arterial thrombotic occlusion is mechanical stimulation to the vascular wall of the common or proper hepatic artery by movement the catheter tip, if it is not fixed.…”

Section: Discussionmentioning

confidence: 91%

“…anesthesia [5,6,15]; however, the recent development of interventional techniques has made it possible to implant port-catheter systems percutaneously under local anesthesia [3,4,7,8,9,10,11,12,13,14,16,17]. Thus, attention has come to be paid to hepatic arterial infusion chemotherapy which can be performed repeatedly at the outpatient clinic via a percutaneously implanted portcatheter system for patients with advanced liver cancer as one effective treatment from the point of view of prolonging normal-quality survival [2].…”

Section: Discussionmentioning

confidence: 99%

Catheter-tip fixation of a percutaneously implanted port-catheter system to prevent dislocation

et al. 2001

View full text Add to dashboard Cite

The aim of this study was to evaluate the incidence of catheter tip dislocation in patients with percutaneously implanted port-catheters for hepatic arterial chemotherapy with catheter tip fixation. Forty-seven patients (31 men and 16 women; mean age 66 years) with unresectable advanced liver cancers (primary liver cancer, n=19; metastatic liver cancer, n=28) underwent percutaneously implantable port-catheter system placement with the tip fixed at the gastroduodenal artery with coils and side hole opened at the common hepatic artery. In 39 patients, n-butyl cyanoacrylate (NBCA) mixed with Lipiodol was added for fixation. The position of the side hole after the indwelling port-catheter system was investigated, and the correction method in cases with catheter dislocation was determined. In 2 (25%) of the 8 patients without NBCA fixation, dislocation of the catheter was noted, in contrast to none (0%) of 37 patients with NBCA fixation. Two patients in whom NBCA was used could not undergo long-term intra-arterial chemotherapy because of hepatic arterial thrombotic occlusion which occurred after placement of the indwelling catheter, and were excluded from the evaluation. Fixation of the catheter tip with combined use of coils and NBCA--Lipiodol mixture to the gastroduodenal artery is important to prevent dislocation of the port-catheter system.

show abstract

“…Among various methods to achieve such implantation using interventional radiological techniques [7][8][9][10][11][12][13][14][15][16][17][18][19], implantation with the fixed catheter tip method [7,8,[15][16][17][18][19][20][21] is advantageous from the standpoint of preventing catheter dislocation and hepatic arterial obstruction [7,8,16,17,21].…”

Section: Introductionmentioning

confidence: 99%

Value of Micronester coils in port-catheter implantation for continuous hepatic arterial infusion chemotherapy with fixed catheter tip method

et al. 2007

View full text Add to dashboard Cite

To retrospectively evaluate the use of Micronester coils in port-catheter implantation with the fixed catheter tip method in comparison with other previously used coils. The cohort of this study was 143 consecutive patients with unresectable advanced liver cancer for whom a port-catheter system was percutaneously implanted. In the most recent 32 patients, Micronester coils were used for catheter tip fixation. Details of embolic agents for fixation, persistent blood flow beyond the distal end of the indwelling catheter, and complications were compared between cases without and with Micronester coils. In all, percutaneous port-catheter placement was successful. Mean number of coils used for fixation was 4.2 without Micronester coils vs. 2.5 with Micronester coils. N-butyl cyanoacrylate (NBCA)-Lipiodol was additionally used for catheter tip fixation in 85.6% of 111 procedures without Micronester coils and in 50% of 32 using Micronester coils. The gastroduodenal artery beyond the distal end was not detected at the final examination after any procedure. Catheter dislocation occurred in five and hepatic arterial obstruction or severe stenosis in eight. The number of coils used and necessity of NBCA-Lipiodol could be decreased with usage of Micronester coils without decreasing fixation ability compared to other coils.

show abstract

Hepatic arterial infusion chemotherapy using percutaneous catheter placement with an implantable port: Assessment of factors affecting patency of the hepatic artery

Cited by 63 publications

References 18 publications

Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

Hepatic Arterial Infusion Chemotherapy Using Low-Dose 5-Fluorouracil and Cisplatin for Advanced Hepatocellular Carcinoma

Catheter-tip fixation of a percutaneously implanted port-catheter system to prevent dislocation

Value of Micronester coils in port-catheter implantation for continuous hepatic arterial infusion chemotherapy with fixed catheter tip method

Contact Info

Product

Resources

About