Hepatic arterial infusion chemotherapy in patients with advanced hepatocellular carcinoma: analysis of 114 cases

Serum transferrin as a predictor of prognosis for hepatic arterial infusion chemotherapy in advanced hepatocellular carcinoma

“…In all reports, survival was significantly better in patients with CR or PR than in patients with SD or PD. We previously reported that multivariate analysis showed Child–Pugh score, therapeutic effect and additional therapy to be significant prognostic factors . The therapeutic effect was especially important and was the most significant prognostic factor.…”

“…For such patients, HAIC is a treatment option, as indicated by a treatment algorithm for HCC in Japan . Few studies have investigated the efficacy of HAIC using more than 100 patients with advanced HCC . In all reports, survival was significantly better in patients with CR or PR than in patients with SD or PD.…”

“…SINCE 1997, WE have been researching the efficacy of several regimens of HAIC based on low‐dose cisplatin (CDDP) and 5‐fluorouracil (5‐FU) (namely low‐dose FP) in patients with advanced HCC . From July 1997 to June 2012, we administrated HAIC to 130 patients admitted to our hospital with unresectable HCC.…”

“…Of these 44 patients, one received HAIC using low‐dose FP, 38 received HAIC using low‐dose FP with isovorin, and five received combination therapy comprising HAIC using low‐dose FP with isovorin and s.c. pegylated interferon (PEG IFN)‐α‐2b . We previously reported no significant differences in response and survival among the three regimens . HCC was diagnosed based on imaging results and elevated serum levels of α‐fetoprotein (AFP) and/or des‐γ‐carboxy prothrombin (DCP).…”

“…In contrast, the Japanese evidence‐based guidelines for diagnosis and treatment of HCC and the consensus‐based treatment algorithm for HCC proposed by the Japan Society of Hepatology recommend hepatic arterial infusion chemotherapy (HAIC) for patients with intermediate‐ or advanced‐stage HCC (according to the BCLC staging system) . We retrospectively evaluated HAIC efficacy in advanced HCC patients, and multivariate analysis showed Child–Pugh score, therapeutic effect and additional therapy to be significant predictors of survival . However, the above parameters were not useful for predicting prognosis before administration of HAIC.…”