Hepatic and reproductive toxicity of sub-chronic exposure to dichlorvos and lead acetate on male Wistar rats

Oyeyemi, Wahab Adekunle; Daramola, Oore-oluwapo Ololade; Akinola, Adeniran Oluwadamilare; Idris, Adeoye Oyewole; Aikpitanyi, Ikponmwosa

doi:10.4103/2305-0500.298776

Cited by 8 publications

(15 citation statements)

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“…In this study, lead acetate increased testicular MDA concentration, and this could be due to the accumulation of Pb 2+ in the testes as observed in this study. The observed increase in MDA is in agreement with previous study (Oyeyemi et al 2020).…”

Section: Discussionsupporting

confidence: 93%

“…The testicular oxidant and antioxidant status were evaluated as previously reported in our studies (Oyeyemi et al 2019(Oyeyemi et al , 2020. The testes were homogenized in a cold 50 mM Tris-potassium chloride buffer (pH 7.4), and cold centrifuge was used to spin the homogenate at 4000 resolution per minute for 15 min at 4 °C.…”

Section: Testicular Oxidant and Antioxidant Activitymentioning

confidence: 99%

“…The spermatozoa were released by piercing the cauda epididymis into the buffer solution. About 9µL of the spermatozoa suspension was placed on a counting chamber (Oyeyemi et al 2020). The sperm count and kinetics were evaluated with the computer-aided Sperm Analyzer (CASA; JH-6004 Sperm Quality Analyzer).…”

Section: Sperm Analysismentioning

confidence: 99%

“…Human exposure to lead is reported to have effects on the general body system, such as the kidney (Abdel-Daim et al 2020), cardiovascular system (Nosratola 2008), lung (Katarzyna et al 2011), nervous system (Kumawat et al 2014) and gastrointestinal system (Xiao et al 2016). Exposure to high concentration of Pb 2+ has been linked to reductions in sperm count, concentration, motility, volume and reduces spermatozoa activity (Oyeyemi et al 2019(Oyeyemi et al , 2020. The mechanisms through which Pb 2+ causes reproductive damages are: oxidative stress, decrease in testicular antioxidants, direct toxic effects on sperm cells and alteration in the hypothalamic-pituitary-testicular axis (Pandya et al 2012;Oyeyemi et al 2019Oyeyemi et al , 2020.…”

Section: Introductionmentioning

confidence: 99%

“…Exposure to high concentration of Pb 2+ has been linked to reductions in sperm count, concentration, motility, volume and reduces spermatozoa activity (Oyeyemi et al 2019(Oyeyemi et al , 2020. The mechanisms through which Pb 2+ causes reproductive damages are: oxidative stress, decrease in testicular antioxidants, direct toxic effects on sperm cells and alteration in the hypothalamic-pituitary-testicular axis (Pandya et al 2012;Oyeyemi et al 2019Oyeyemi et al , 2020. Oyeyemi et al Bulletin of the National Research Centre (2022) 46:22 Alpha tocopherol (Vitamin E; Vit E) is a fat-soluble vitamin with characteristic antioxidant activities (Traber et al 2006;Verhagen et al 2006).…”

Section: Introductionmentioning

confidence: 99%

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Vitamin E and quercetin attenuated the reproductive toxicity mediated by lead acetate in male Wistar

et al. 2022

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Background Heavy metals are well documented to induce reproductive toxicity. This study was designed to investigate the role of vitamin E and quercetin on reproductive toxicity mediated by lead acetate in male Wistar rats. Thirty male adult Wistar rats were grouped into six (n = 5 per group) as follows: Group 1 (Control); Group 2 and 3 were administered with 100 mg/kg vitamin E and quercetin, respectively; Group 4 was administered with 30 mg/kg lead acetate; Groups 5 and 6 received lead acetate with vitamin E and lead acetate with quercetin, respectively. Results Lead acetate significantly increased (p < 0.05) testicular malondialdehyde, nitric oxide, lead ion and abnormal sperm morphology, while testicular catalase, superoxide dismutase activities, calcium ion, zinc ion, serum follicle stimulating hormone, luteinizing hormone, testosterone, sperm count, motility, average path, curvilinear velocity, and sperm viability were significantly reduced (p < 0.05). The co-administration of lead acetate with vitamin E and quercetin significantly reversed (p < 0.05) the testicular level of malondialdehyde, nitric oxide, lead ion, abnormal sperm morphology, catalase superoxide dismutase activities, calcium ion, zinc ion, follicle stimulating hormone, luteinizing hormone, testosterone, sperm count, motility, average path velocity and sperm viability. Conclusions Vitamin E and quercetin attenuated the reproductive toxicity induced by lead acetate in the male Wistar rats, and this suggests that vitamin E and quercetin may serve as possible therapeutic agents in improving male reproductive functions in heavy metal toxicity.

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Section: Discussionsupporting

confidence: 93%

Section: Testicular Oxidant and Antioxidant Activitymentioning

confidence: 99%

Section: Sperm Analysismentioning

confidence: 99%