Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor

Grünenberger, F.; Bachellier, Philippe; Chenard, Marie–Pierre; Massard, Gilbert; Caraman, P. L.; Perrin, Elisabeth; Zapf, J.; Jaeck, Daniel; Schlienger, Jean-Louis

doi:10.1002/(sici)1097-0142(19990515)85:10<2245::aid-cncr20>3.0.co;2-k

Cited by 28 publications

(15 citation statements)

References 30 publications

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“…Recent case series report rates of recurrence with extracranial metastatic disease after primary resection to be between 13% and 31% [6,17,18]. Although uncommon, others have described hypoglycemia in association with metastatic HPC [19]. Non-islet-cell tumor hypoglycemia (NICTH) is driven by tumor secretion of the precursor of IGF-II, pro-IGF-II peptide or "big IGF."…”

Section: Discussionmentioning

confidence: 92%

Multidisciplinary Management of Metastatic Hemangiopericytoma Presenting with Hypoglycemia

Pv¹

2017

Ann Hematol Oncol

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Section: Discussionmentioning

confidence: 92%

Multidisciplinary Management of Metastatic Hemangiopericytoma Presenting with Hypoglycemia

Pv¹

2017

Ann Hematol Oncol

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“…The biological behavior of HPC is sometimes malignant although it is considered grade II-III. Local tu- mor recurrence after many years is not uncommon, and late and widespread extracranial metastases may occur (7). Metastatic HPC to the spine is rare.…”

Section: Discussionmentioning

confidence: 99%

“…HPCs are usually located in the musculoskeletal system (lower extremities, pelvis, vertebrae), retroperitoneum and the skin, but they have been reported in the larynx, spleen, lung, kidney, pancreas, mediastinium, orbita, adrenal gland, lymph nodes, liver, bone, breast, and pleura. Intracranial and to the other region metastasis of HPC is seen very rare together (6)(7)(8).…”

Section: Abstract: Hemangiopericytoma Meningioma Extracranial Metamentioning

confidence: 99%

Recurrent Hemangiopericytoma With Multiple Extracranial Metastates: A Case Report

Devrim;KAHİLOĞULLARI¹

2008

Ankara Üniversitesi Tıp Fakültesi Mecmuası

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Hemangiopericytoma is an uncommon, highly vascular tumor of pericyte origin that may occur anywhere capillaries are found. These tumors are usually located in the musculoskeletal system, retroperitoneum and the skin. Their intracranial localization is rare. Hemangiopericytomas have a predilection for both local and distant central nervous system recurrences and exhibit an increased tendency to metastasize compared with nonmalignant meningiomas. The biological behavior of hemangiopericytoma is sometimes malignant although it is considered grade II-III. Local tumor recurrence after many years is not uncommon, and late and widespread extracranial metastases may occur although this is rare in other intracranial tumors. A 46-year old male who had a recurrent intracranial hemangiopericytoma with multiple metastases such as cervical vertebrae, paravertebral soft tissue, lung, kidney and shoulder has been reported. Key Words: Hemangiopericytoma, Meningioma, Extracranial metas, RecurrenceHemanjiyoperisitomalar nadir görülen, oldukça vasküler, kapiller damarların bulunduğu her yerde görülebilen perisit orijinli tümörlerdir. Bu tümörler genelde kas iskelet sisteminde yerleşirler. Intrakranial yarleşimleri oldukça nadirdir. Hem local hem de santral sinir sisteminin uzak bölgele-rinde rekürrens yapmaya meyillidirler ve malign olmayan menenjiyomlara kıyasla uzak metastaz yapma ihtimalleri daha fazladır. Hemanjiyoperisitomların biyolojik davranışları bazen grade II-III olarak sınıfl andırılmalarına neden olacak kadar malign olabilmektedir. Uzun yıllar sonra lokal tü-mor rekürrensi çok sık değildir ancak yaygın ekstrakranial metastaza rastlanabilmektedir. Bu yazı-da, servikal vertebra, paravertebral yumuşak doku, akciğer, böbrek ve kas-iskelet sistemi metastazı olan, aynı zamanda da intracranial rekürrensi olan bir hemanjiyoperisitom olgusu sunulmuştur.

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“…Serum IGF-I and IGF-II levels were measured in 12 15,[21][22][23][24][25][26][27]29,32,33 of the 33 reported patients 3-33 with hemangiopericytoma associated with hypoglycemia, including our patient. IGF-I was within the normal range in 2 patients, 26,29 but was low in the other 10, while the IGF-II level was elevated in 2 patients, 26,32 and within the normal range in the other 10.…”

Section: Discussionmentioning

confidence: 99%

Insulin-like growth factor II-producing intra-abdominal hemangiopericytoma associated with hypoglycemia

Matsuda¹,

Usui²,

Sakurai³

et al. 2001

Journal of Gastroenterology

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We report a patient with insulin-like growth factor (IGF)-II-producing hemangiopericytoma with hypoglycemia in whom repeated intra-abdominal recurrences developed over a period of about 10 years and tumor resection was performed four times. A 67-year-old woman was admitted to our hospital in 1995 because of hypoglycemic attacks. In 1985, partial resection of the small bowel had been performed for a 17-cm abdominal tumor of the transverse mesocolon, and the pathological diagnosis was hemangiopericytoma. In 1991, left hemicolectomy had been performed for a mesosigmoidal tumor associated with hypoglycemia. In 1994, hysterectomy, bilateral adnexectomy, and resection of an intrapelvic tumor were performed. The fourth operation was performed in 1996, about 10 years after the first operation. The spleen was removed, together with more than 1500 tumors having a total weight of 1,660 g. The hypoglycemia was ameliorated after each operation. Before this operation, her serum IGF-I level was low, but her IGF-II level was within the normal range; however, the Western immunoblot method showed that most of the IGF-II was high-molecular-weight IGF-II. The tissue IGF-I level was also low, and the IGF-II level was high, suggesting an IGF-II-producing tumor. We suspect that the mechanism of the hypoglycemia in this patient was related to the high-molecular-weight IGF-II produced by the tumor. The patient died in 1997 because of tumor recurrence.

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Hepatic and pulmonary metastases from a meningeal hemangiopericytoma and severe hypoglycemia due to abnormal secretion of insulin-like growth factor

Cited by 28 publications

References 30 publications

Multidisciplinary Management of Metastatic Hemangiopericytoma Presenting with Hypoglycemia

Multidisciplinary Management of Metastatic Hemangiopericytoma Presenting with Hypoglycemia

Recurrent Hemangiopericytoma With Multiple Extracranial Metastates: A Case Report

Insulin-like growth factor II-producing intra-abdominal hemangiopericytoma associated with hypoglycemia

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