Hepatic and Intestinal Drug-Metabolizing Enzymes and the Tissue Distribution and Excretion of 14C-7,12-Dimethylbenz[a]anthracene in Rats Fed Diets Varying in Fat Concentration

Clinton, Steven K.; Visek, Willard J.

doi:10.1159/000138582

Cited by 6 publications

(2 citation statements)

References 21 publications

(28 reference statements)

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“…Bowes and Renwick (1986) observed no change in the inducible levels of B[a]P hydroxylase and DNA binding in the intestine of guinea pigs that were fed normal or high-fat diets. On the contrary, Clinton and Visek (1989) reported efficient absorption and bioavailability of DMBA in rats fed high-fat diets. A direct relationship between PAH absorption and fat absorption was demonstrated by the studies of Laurent et al (2001).…”

Section: Role Of Dietary Fat In Pah Bioavailabilitymentioning

confidence: 92%

Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons

Ramesh¹,

Walker²,

et al. 2004

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Polycyclic aromatic hydrocarbons (PAHs) are a family of toxicants that are ubiquitous in the environment. These contaminants generate considerable interest, because some of them are highly carcinogenic in laboratory animals and have been implicated in breast, lung, and colon cancers in humans. These chemicals commonly enter the human body through inhalation of cigarette smoke or consumption of contaminated food. Of these two pathways, dietary intake of PAHs constitutes a major source of exposure in humans. Although many reviews and books on PAHs have been published, factors affecting the accumulation of PAHs in the diet, their absorption following ingestion, and strategies to assess risk from exposure to these hydrocarbons following ingestion have received much less attention. This review, therefore, focuses on concentrations of PAHs in widely consumed dietary ingredients along with gastrointestinal absorption rates in humans. Metabolism and bioavailability of PAHs in animal models and the processes, which influence the disposition of these chemicals, are discussed. The utilitarian value of structure and metabolism in predicting PAH toxicity and carcinogenesis is also emphasized. Finally, based on intake, disposition, and tumorigenesis data, the exposure risk to PAHs from diet, and contaminated soil is presented. This information is expected to provide a framework for refinements in risk assessment of PAHs from a multimedia exposure perspective.

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Section: Role Of Dietary Fat In Pah Bioavailabilitymentioning

confidence: 92%

Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons

Ramesh¹,

Walker²,

et al. 2004

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“…p-Toluidine excretion was affected by the dietary fat to a less degree. Clinton and Visek (1989) studied the effects of diet containing 25% corn oil on the tissue distribution and excretion of 14 C-7,12-dimethylbenz[a]antracene (DMBA) in rats. They did not observe any differences in cumulative urinary and fecal excretion of the compound between standard and high-fat diet.…”

Section: Discussionmentioning

confidence: 99%

Effect of Dietary Fat on Selected Parameters of Toxicity Following 1- or 3-Month Exposure of Rats to Toluidine Isomers

Jodynis‐Liebert

Bennasir

2005

Int J Toxicol

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The aim of the study was to investigate the effect of the dietary fat on selected parameters of toluidines toxicity in rats during subchronic exposure. Three isomers of toluidine (ortho, meta, and para) were administered to rats in the diet for 1 and 3 months at levels 40, 80, 160 mg/kg/day in two kinds of diet containing either 4% or 14% fat. All doses of toluidine isomers produced a 1.5- to 9.8-fold increase in methemoglobin (MetHb) level during both treatment periods. A distinct dose-response relationship was observed, especially for o- and m-toluidine; the effect was generally greater in rats fed high-fat diet. Reduced glutathione level in liver was increased in all treated groups, 1.5- to 5.1-fold, irrespective of the kind of diet. An increase in hepatic lipid peroxidation (thiobarbituric acid reactive substances; TBARS), 1.5- to 4.5-fold, was noticed in the majority of the treated groups. Generally, there was no consistent effect of diet except for p-toluidine where the level of hepatic TBARS was lower in rats fed high-fat diet. Blood urea nitrogen (BUN) level in animals treated with all doses of o- and m-toluidine was 1.3- to 5.0-fold higher in comparison with respective controls. No clear relationship between BUN level and the kind of diet was found. No effect of toluidines on the activity of serum aspartate aminotransferase (AST) and sorbitol dehydrogenase (SDH) were observed. In the majority of groups treated for 30 and 90 days the amount of toluidines in 24-h urine was lower in rats fed high-fat diet. Final body weight gain in rats treated with o- and p-toluidine (80 and 160 mg/kg body weight [b.w.]) was lower as compared to controls. In summary the high-fat diet stimulated methemoglobin formation in rats treated with o- and m-toluidine and cause the decrease in the amount of toluidines in 24-h urine. The high content of fat did not affect consistently the other parameters tested.

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Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research

Clarke

1997

Breast Cancer Res Treat

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This is the second Special Issue addressing the diversity and use of animal models of breast cancer. The previous issue (Breast Cancer Res Treat 39:1-135, 1996), dealt with a variety of topics such as the characteristics of chemically- and virally-induced rodent models, immunobiologies of immunedeficient mice, transgenic mouse models, and models of metastasis. In the first part of this second Special Issue, the articles address animal models for studying life-style factors, including psychosocial, exercise, and nutritional research in breast cancer. In the second section, there is emphasis on the controversial area of dietary fat, with other authors addressing caloric restriction and dietary isoflavonoids, retinoids, and monoterpenes in the third part. In the final section, a series of authors provide suggestions for approaching various issues involving experimental design, including nutritional studies, drug screening models, statistical considerations, quantitation of tumor growth kinetics, and animal husbandry. These articles, and some additional issues raised during the previous Special Issue, are briefly discussed in this overview. They include a further evaluation of the relative merits of 7,12-dimethylbenz(a)anthracene and N-nitroso-N-methylurea as carcinogens, and of the use of the AIN76 and AIN93 semipurified diets in studies of mammary carcinogenesis.

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Hepatic and Intestinal Drug-Metabolizing Enzymes and the Tissue Distribution and Excretion of 14C-7,12-Dimethylbenz[a]anthracene in Rats Fed Diets Varying in Fat Concentration

Cited by 6 publications

References 21 publications

Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons

Bioavailability and Risk Assessment of Orally Ingested Polycyclic Aromatic Hydrocarbons

Effect of Dietary Fat on Selected Parameters of Toxicity Following 1- or 3-Month Exposure of Rats to Toluidine Isomers

Animal models of breast cancer: experimental design and their use in nutrition and psychosocial research

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