Hepatic and gastroprotective activity of Serjania marginata leaf aqueous extract in Nile tilapia (Oreochromis niloticus)

Ota, Erika do Carmo; Honorato, Cláucia Aparecida; Vieira, Silvia Cristina Heredia; Flores-Quintana, Carolina Isabel; Silva, Tarcila Souza de Castro; Inoue, L. A. K. A.; Cardoso, Cláudia Andréa Lima

doi:10.1007/s10695-019-00622-9

Cited by 16 publications

(13 citation statements)

References 104 publications

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“…The increase in transaminase activity indicated liver damage. Changes in the content of these enzymes are indications of liver damage caused by an inadequate nutritional balance in the diet, such as excess protein (Nunes et al, 2013), and the effect of anti-nutritional factors or source of the nutrient (Ota et al, 2019). The increase in AST and ALT activities are considered to be a response of the organism to stressors and nutritional metabolism (Meng et al, 2018), which deserves attention because, for this species, longevity is required.…”

Section: Discussionmentioning

confidence: 99%

“…It was observed that the DHP diet did not enable S. aequifasciatus to express its digestive plasticity to absorb nutrients that were too high. Ota et al (2019) suggested that dephosphorylation of nutrients by intestinal AF is necessary to make them permeable to the plasma membrane, indicating an increase in intestinal AF activity during the maximum feeding period.…”

Section: Discussionmentioning

confidence: 99%

“…The stimulation to produce enzymes by the presence of some specific food is associated with both the production and modulation of genetic expression in the hepatopancreas (Honorato et al, 2010). Adequate protein utilization is very important for fish nutrition and strongly depends on the activity of the proteases and the increase in alkaline protease activity (Ota et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…A limiting factor in the food conversion of fish is the availability of digestive enzymes in the gastrointestinal tract (Pujante et al, 2017). The effects of macronutrient contents on the production and secretion of digestive enzymes have been widely reported in fish (Ota et al, 2019). Small biomolecules can also affect the production of digestive enzymes (Xiao et al, 2011).…”

Section: Introductionmentioning

confidence: 99%

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Influence of a Blend of Dietary Essential Amino Acids on Growth, Enzymatic Activity, and Intestinal Histology of Blue Discus

Santos¹,

Siqueira²,

Reis³

et al. 2021

Bol. Inst. Pesca

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Symphysodon aequifasciatus is a fish with a disk-shaped body and bright colors, important characteristics of ornamental fish. We evaluated amino acid supplementation strategies to reduce crude protein in the diet for evaluation of performance, the content of digestive enzymes, liver metabolism, and intestinal histopathology. A total of 180 fish were randomly distributed in 12 separate 50 L glass aquariums, consisting of a completely randomized design with four treatments (DC - Control diet with 34.4% crude protein; DL - Control diet plus 1% of lysine; DEAA - Control diet plus 1% free essential amino acids (threonine, phenylalanine, leucine, valine, arginine, and tryptophan); and DHP - Diet with a high level of crude protein 48.4%), three repetitions, lasting 60 days. The use of DL and DEAA diets resulted in higher intestinal villus height and higher zootechnical performance. The use of DL diet increased alkaline phosphatase and digestive amylase activity. The use of DHP diets promotes severe liver changes due to increased activity of Alanine aminotraserase. Therefore, it was possible to observe that the use of amino acids can supply the nutritional need of blue discus. Supplementation of diets with AAs allows the reduction of dietary protein, which is a strategy for feeding management.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Influence of a Blend of Dietary Essential Amino Acids on Growth, Enzymatic Activity, and Intestinal Histology of Blue Discus

Santos¹,

Siqueira²,

Reis³

et al. 2021

Bol. Inst. Pesca

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“…Gastroprotective activity of S. marginata leaves aqueous (Ota et al, 2019) and hydroalcoholic extracts (Périco et al, 2015) were scienti cally shown. Périco and colleagues (2015) also showed that hydroalcoholic extract from leaves of S. marginata was antimicrobial, antidiarrheal, and (anti)mutagenic.…”

Section: Introductionmentioning

confidence: 99%

Serjania marginata Casar. hydroalcoholic extract reduced cytokine and inflammatory parameters in experimental models of inflammation and infection in mice

Leitão¹,

Radai²,

Macorini³

et al. 2021

Preprint

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This study investigated the antimycobacterial, anti-inflammatory and antihyperalgesic effects of EESM in in vitro and in vivo models. EESM (0.98–1000 µg/ml) was evaluated in in vitro against Mycobacterium tuberculosis, M. bovis, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus epidermidis. The EESM oral administration (p.o.) (30, 100 and 300 mg/kg) and dexamethasone subcutaneous injection (s.c.) (1 mg/kg) were tested against the carrageenan-induced inflammatory paw edema and pleurisy in Swiss mice. The EESM (30 and 100 mg/kg, p.o.) and dexamethasone (1 mg/kg, s.c.) were tested against the CFA-induced paw inflammation and M. bovis (bacillus Calmette-Guerin - BCG)-induced pleurisy in C57bL6 mice. The minimum inhibitory concentration (MIC) of EESM in the presence of M. tuberculosis was 62.4 µg/ml. The values of MIC of EESM in the presence S. epidermidis, K. pneumoniae were 1000 µg/mL while EESM did not interfere with against P. aeruginosa growth. EESM significantly inhibited paw edema/mechanical hyperalgesia in carrageenan induced paw inflammation and leukocytes migration/proteins exudation in carrageenan-induced pleurisy model. In the BCG-induced pleurisy model, the daily treatment for 7 days, with EESM inhibited the levels of IL-1β in blood and in pleural exudate. The EESM did not alter the mycobacterial growth in the cell culture from pleural lavage, spleen and liver samples collected from BCG-treated animals. The EESM significantly inhibited the persistent edema and mechanical hyperalgesia induced by CFA. This study confirms the EESM anti-inflammatory property and showed that EESM has high potency in inducing inhibition of mycobaterial growth and low potency or no effects in relation to other microorganisms.

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The effects of probiotic-based additives on aflatoxin intoxication in Piaractus mesopotamicus: a study of liver histology and metabolic performance

Godoy,

Ziemniczak,

Fantini-Hoag

et al. 2024

Vet Res Commun

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Hepatic and gastroprotective activity of Serjania marginata leaf aqueous extract in Nile tilapia (Oreochromis niloticus)

Cited by 16 publications

References 104 publications

Influence of a Blend of Dietary Essential Amino Acids on Growth, Enzymatic Activity, and Intestinal Histology of Blue Discus

Influence of a Blend of Dietary Essential Amino Acids on Growth, Enzymatic Activity, and Intestinal Histology of Blue Discus

Serjania marginata Casar. hydroalcoholic extract reduced cytokine and inflammatory parameters in experimental models of inflammation and infection in mice

The effects of probiotic-based additives on aflatoxin intoxication in Piaractus mesopotamicus: a study of liver histology and metabolic performance

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