Hepatic and biliary damage after transarterial chemoembolization for malignant hepatic tumors: Incidence, diagnosis, treatment, outcome and mechanism

Sun, Zhen; Li, Gaopeng; Ai, Xi; Luo, Baoming; Wen, Yu; Zhao, Zizhuo; Dong, Shaohong; Guan, Jian

doi:10.1016/j.critrevonc.2010.07.019

Cited by 60 publications

(59 citation statements)

References 79 publications

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“…These unintended side effects are mainly due to nontarget embolization of adjacent vessels supplying biliary structures or normal hepatic parenchyma. There are numerous reported cases of cholecystitis and gallbladder infarction following TACE [4,6] . These occur due to nontarget embolization of the cystic and/or accessory cystic arteries.…”

Section: Discussionmentioning

confidence: 99%

“…These arteries arise from the common, right or left hepatic arteries. Reflux of embolic agent into these arteries is often inevitable, especially if the origin of the cystic artery is near the site of embolization [4,6] .…”

Section: Discussionmentioning

confidence: 99%

“…A frequent complication of this procedure is nontarget embolization of tissues supplied by the hepatic arteries and their branches. One observed complication is cholecystitis and subsequent gallbladder infarction, which can occur secondary to reflux of embolic agents into the cystic or accessory cystic arteries [4] .…”

Section: Introductionmentioning

confidence: 99%

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Transarterial chemoembolization of hepatocellular carcinoma using antireflux catheter

O’Dell

Liu

Fursevich

et al. 2015

IJDI

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Transarterial chemoembolization is an effective treatment option for patients with intermediate and advanced hepatocellular carcinoma. There are several complications that can occur with this procedure, most of which are the result of nontarget embolization. One such complication is acute cholecystitis following nontarget embolization of the cystic or accessory cystic arteries, which usually occurs secondary to reflux of the embolic agent. Our case demonstrates utilization of the Surefire Infusion System to prevent this complication. This antireflux catheter was very effective in a case where vessel anatomy created a substantial risk for a clinically significant nontarget embolization of the cystic artery.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Transarterial chemoembolization of hepatocellular carcinoma using antireflux catheter

O’Dell

Liu

Fursevich

et al. 2015

IJDI

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“…However, for moderate to severe signs of infection with or without increases in the size of the biloma, promptly percutaneous drainage or partial hepatectomy even internal drainage combined with antibiotics should be applied first (9,(22)(23)(24). If it is not treated in a timely and appropriate manner, it may result in severe systemic infection, and even a bronchobiliary fistula or biliopleural fistula and multiple organ failure (23,25).…”

Section: Discussionmentioning

confidence: 99%

Intrahepatic biloma following transcatheter arterial chemoembolization for hepatocellular carcinoma: Incidence, imaging features and management

Zhang

Guo

et al. 2017

Molecular and Clinical Oncology

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Abstract. Repeat transcatheter arterial chemoembolization (TACE) becomes more challenging for patients with intrahepatic biloma following TACE for hepatocellular carcinoma (HCC).The purpose of this study was to investigate the clinical course, incidence, imaging features and outcome and to explore the reasonable therapy scheme for intrahepatic biloma following TACE for HCC.A total of 4,695 TACE procedures were performed for 1,923 patients with HCC. Twenty patients with intrahepatic biloma following TACE were studied retrospectively. The incidence of intrahepatic biloma was 1.04% in this study. The 20 patients underwent 55 TACE procedures (mean, 2.75). Portal vein invasion was found in half of the patients. Eleven patients developed round solitary or multiple cystic biloma, 6 patients had branched biloma and 3 patients developed both cystic and branched biloma. Percutaneous drainage was applied for 4 patients. One patient underwent partial hepatectomy and one mortality occurred due to progressive biloma and multiple organ failure. Although severe intrahepatic biloma following TACE is rare, the procedure should be performed with caution. Timely and appropriate management, including percutaneous drainage, partial hepatectomy and antibiotic administration should be performed in the case of any signs of infection.

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“…5,9 Although TACE has direct anti tumour effect, it can also cause complications such as increasing of transaminase serum level and negative changes in liver function, that probably caused by ischemic injury in liver and also tumour necrosis. 10,11,12 Alpha-fetoprotein (AFP) is protein from fetal component that is produced by fetal liver and gestasional sac during embryo period. Adult AFP normal level is < 20 ng/mL.…”

Section: Introductionmentioning

confidence: 99%

Response Evaluation of Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma with Respect to Tumour Size, Number of Lesion, and Alpha-Fetoprotein (AFP) Level

Kholili

Maimunah

et al. 2016

InaJGHE

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Hepatic and biliary damage after transarterial chemoembolization for malignant hepatic tumors: Incidence, diagnosis, treatment, outcome and mechanism

Cited by 60 publications

References 79 publications

Transarterial chemoembolization of hepatocellular carcinoma using antireflux catheter

Transarterial chemoembolization of hepatocellular carcinoma using antireflux catheter

Intrahepatic biloma following transcatheter arterial chemoembolization for hepatocellular carcinoma: Incidence, imaging features and management

Response Evaluation of Patients Undergoing Transarterial Chemoembolization (TACE) for Hepatocellular Carcinoma with Respect to Tumour Size, Number of Lesion, and Alpha-Fetoprotein (AFP) Level

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