Hepatic amino-acid metabolism in liver cirrhosis and in the long-term course after liver transplantation

Tietge, Uwe J. F.; Bahr, Matthias J.; Manns, Michael P.; Böker, K. H. W.

doi:10.1111/j.1432-2277.2003.tb00215.x

Cited by 27 publications

(22 citation statements)

References 27 publications

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“…Examples of diseases in which the levels of AAA are increased and the levels of BCAA decreased are non-alcoholic fatty liver disease, non-alcoholic steatohepatitis, cirrhosis, viral hepatitis, chronic hepatitis, biliary disease, primary biliary cirrhosis, sclerosing cholangitis and fulminant hepatic failure. Interesting results were obtained by Tietge et al [3,24]. Patients with cirrhosis had increased levels of plasma AAA and these levels correlated with the progression of the liver disease.…”

Section: Discussionmentioning

confidence: 55%

“…In addition to AAA and BCAA, disturbances in the metabolism of other amino acids can be observed in patients with liver disease. Morgan et al [25] observed increased levels of plasma methionine in patients with chronic liver disease, and Tietge et al [3] in patients with cirrhosis. After liver transplantation, the levels returned to normal [3].…”

Section: Discussionmentioning

confidence: 99%

“…Morgan et al [25] observed increased levels of plasma methionine in patients with chronic liver disease, and Tietge et al [3] in patients with cirrhosis. After liver transplantation, the levels returned to normal [3]. Sato et al [7] described mildly increased serum methionine in survivors of fulminant hepatic failure and extremely increased among non-survivors.…”

Section: Discussionmentioning

confidence: 99%

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Determination of Selected Amino Acids in Serum of Patients with Liver Disease

et al. 2016

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Section: Discussionmentioning

confidence: 55%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Determination of Selected Amino Acids in Serum of Patients with Liver Disease

et al. 2016

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“…A potential mechanism catalyzing membrane alterations of erythrocytes in vivo is an increased concentration of proteolytic metabolites in advanced cirrhosis. 43 In addition, the synthesis of erythrocellular galactosyl-and galactosamine-containing lipids and proteins, as well as their correct glycosylation, is altered in liver cirrhosis, because many of these components are produced by hepatocytes. 1,4 These membrane alterations can lead to microscopically visible pathological shape changes, such echinocytosis and acanthocytosis (spur cells).…”

Section: Discussionmentioning

confidence: 99%

Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirrhosis

et al. 2004

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Hemolysis in patients with advanced alcoholic liver disease is a common clinical problem and indicates an unfavorable prognosis. In many cases, the etiology of the hemolysis remains unknown. We observed three patients with alcoholic liver disease, suffering from severe hemolytic anemia, requiring multiple blood transfusions. Steroid therapy was ineffective and two of the patients died. All patients had a soluble variant of the human asialoglycoprotein receptor (s-ASGP-R) in their serum, as well as high titers of autoantibodies against this receptor (anti-ASGP-R). Consecutively, examination of 60 patients with alcoholic liver disease revealed a high incidence for s-ASGP-R (36%) and anti-ASGP-R (27%) in patients with alcoholic liver cirrhosis (ALC) compared to patients with cirrhosis due to viral hepatitis. The potential etiology of hemolysis was studied in vitro on erythrocytes from patients with ALC and from healthy donors. Isolated ASGP-R but not anti-ASGP-R bound to the surface of erythrocytes preferentially of blood group A1 and caused dose-dependent agglutination and hemolysis, while this phenomenon was much lower using erythrocytes of the blood group B and almost absent with blood group O-erythrocytes. Furthermore, agglutination and hemolysis only occurred in erythrocytes from ALC-patients or after the pretreatment of cells with neuraminidase. ASGP-R induced agglutination and hemolysis was blocked by the competitive ASGP-R inhibitor asialofetuin. In conclusion, our results indicate a new, non-immunological mechanism for hemolysis in patients with alcoholic liver disease, mediated through agglutination by a soluble variant of the human asialoglycoprotein receptor and mechanical shear stress.

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“…In children, there is little information regarding the impact of OLT on BCAA metabolism. However there is evidence that plasma concentrations of the BCAA remain depressed after OLT, whereas aromatic amino acid concentrations are usually normal, suggesting that BCAA requirements may be increased post-OLT (3)(4)(5).…”

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confidence: 99%

Effect of Orthotopic Liver Transplantation (OLT) on Branched-Chain Amino Acid Requirement

et al. 2006

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Little is known regarding the impact of liver transplantation on amino acid requirements in children. Since plasma levels of the branched-chain amino acids (BCAA) are decreased in the presence of normal levels of the aromatic amino acids after liver transplantation, normalization of hepatic function may not fully correct changes in BCAA metabolism that occur in the pretransplant period. The goal of the present study was to determine total BCAA requirements of children following liver transplantation. The requirement of total BCAA was determined using indicator amino acid oxidation (IAAO) in five clinically stable children (5.7 Ϯ 3.5 y, mean Ϯ SD) 1-8 y post liver transplantation. Children received in random order 6 graded intakes of total BCAA. Individual BCAA in the test diet were provided in the same proportions as present in egg protein to minimize the potential interactive effects of individual BCAA on assessment of requirement. Total BCAA requirement was determined by measuring the oxidation of L-[1-13 C] phenylalanine to 13 CO 2 [F 13 CO 2 in mol/kg/h], after a primed, continuous infusion of the tracer and using a two-phase linear regression crossover regression analysis. The estimated average requirement and the upper limit of the 95% CI for total BCAA in children who have undergone liver transplantation were 172 and 206 mg/kg/d), respectively. Total BCAA requirement in children who have undergone orthotopic liver transplantation (OLT) remain increased in the post-liver transplant period when compared with healthy school aged children, but is decreased when compared with children with mild-moderate chronic cholestatic ( T here is no previous information regarding BCAA requirements in children who have undergone OLT. We have shown previously that total BCAA requirements in children with MCC liver disease are higher than requirements in healthy school-aged children (1,2) This increase in total BCAA requirement was observed in a population of children with a similar body composition, age, growth, and nutritional status as healthy school-aged children studied previously (2). The only major difference was that the children with MCC liver disease had decreased plasma concentrations of the BCAA in the presence of increased requirements for the total BCAA, suggesting that changes in plasma BCAA levels may be reflective of differences in BCAA requirement in this population (1,2). In children, there is little information regarding the impact of OLT on BCAA metabolism. However there is evidence that plasma concentrations of the BCAA remain depressed after OLT, whereas aromatic amino acid concentrations are usually normal, suggesting that BCAA requirements may be increased post-OLT (3-5).There is limited information regarding the potential mechanism responsible for a change in plasma BCAA concentrations after OLT. Normal concentrations of the AAA in the posttransplant period suggest that hepatic metabolism of the AAA have normalized, whereas depressed levels of the BCAA point to the skeletal muscle as the s...

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Hepatic amino-acid metabolism in liver cirrhosis and in the long-term course after liver transplantation

Abstract: (2) improved liver function compared with that in patients with cirrhosis.

Cited by 27 publications

References 27 publications

Determination of Selected Amino Acids in Serum of Patients with Liver Disease

Determination of Selected Amino Acids in Serum of Patients with Liver Disease

Asialoglycoprotein receptor facilitates hemolysis in patients with alcoholic liver cirrhosis

Effect of Orthotopic Liver Transplantation (OLT) on Branched-Chain Amino Acid Requirement

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