Abstract:Iron overload can lead to hepatic fibrogenesis and high liver iron is frequently associated with porphyria cutanea tarda (PCT), a disease characterized by hepatic accumulation of highly carboxylated porphyrins. To assess whether porphyrin accumulation could arise from impaired anion transport, ABC transporter expression in a porphyria‐susceptible mouse model was investigated by qPCR. Mice with the Urod+/– (uroporphyrinogen decarboxylase), Hfe−/− (hemochromatosis) genotype spontaneously develop PCT, with severe… Show more
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