Hepatectomy is associated with improved oncologic outcomes in recurrent colorectal liver metastases: A propensity-matched analysis

Sutton, Thomas L.; Wong, Liam H.; Walker, Brett S.; Dewey, Elizabeth; Eil, Robert L.; Lopez, Charles D.; Kardosh, Adel; Chen, Emerson Y.; Rocha, Flavio G.; Billingsley, Kevin G.; Mayo, Skye C.

doi:10.1016/j.surg.2022.10.019

Cited by 10 publications

(11 citation statements)

References 28 publications

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“…Precision medicine, and consequently precision oncology, like precision surgery, should be based on these features not immediately visible to the human eye [ 159 , 160 , 161 , 162 ]. Therefore, there is a need for advanced technologies such as radiomics, target therapy, and minimally invasive liver surgery [ 163 , 164 , 165 , 166 , 167 , 168 , 169 , 170 , 171 , 172 , 173 , 174 , 175 , 176 ].…”

Section: Resultsmentioning

confidence: 99%

Update on the Applications of Radiomics in Diagnosis, Staging, and Recurrence of Intrahepatic Cholangiocarcinoma

et al. 2023

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Background: This paper offers an assessment of radiomics tools in the evaluation of intrahepatic cholangiocarcinoma. Methods: The PubMed database was searched for papers published in the English language no earlier than October 2022. Results: We found 236 studies, and 37 satisfied our research criteria. Several studies addressed multidisciplinary topics, especially diagnosis, prognosis, response to therapy, and prediction of staging (TNM) or pathomorphological patterns. In this review, we have covered diagnostic tools developed through machine learning, deep learning, and neural network for the recurrence and prediction of biological characteristics. The majority of the studies were retrospective. Conclusions: It is possible to conclude that many performing models have been developed to make differential diagnosis easier for radiologists to predict recurrence and genomic patterns. However, all the studies were retrospective, lacking further external validation in prospective and multicentric cohorts. Furthermore, the radiomics models and the expression of results should be standardized and automatized to be applicable in clinical practice.

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Section: Resultsmentioning

confidence: 99%

Update on the Applications of Radiomics in Diagnosis, Staging, and Recurrence of Intrahepatic Cholangiocarcinoma

et al. 2023

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“…Repeat hepatectomy has been proposed as the most optimal treatment option for recurrent CRLM after initial surgical resection. 10,11,20 Among patients with recurrent disease, tumor size and number, as well as the time interval until recurrence, are important predictors of survival. [10][11][12] There is a paucity of data, however, on the previous index right hemi-hepatectomy for CRLM.…”

Section: Discussionmentioning

confidence: 99%

“…10,11,20 Among patients with recurrent disease, tumor size and number, as well as the time interval until recurrence, are important predictors of survival. [10][11][12] There is a paucity of data, however, on the previous index right hemi-hepatectomy for CRLM. 22 As such, primary operations for CRLM should strive to resect CRLM with a negative surgical margin, yet preserve as much parenchyma as possible.…”

Section: Discussionmentioning

confidence: 99%

“…[6][7][8][9] Prior studies have demonstrated a positive association between repeat hepatectomy and favorable long-term outcomes among patients experiencing a recurrence of previously resected CRLM. 10,11 For example, Sutton et al reported that patients who underwent repeat hepatectomy had a 47% reduction in the risk of death compared with individuals who received systemic chemotherapy, even after adjusting for various clinicopathological imbalances between the two groups. 10 Notwithstanding these data, several prognostic factors have been proposed as being crucial to consider when deciding on an optimal treatment strategy for recurrent CRLM.…”

Section: Introductionmentioning

confidence: 99%

“…As such, patients with recurrent CRLM should be treated by an experienced multidisciplinary team 5. Several investigators have advocated for the superiority of repeat hepatectomy over systemic chemotherapy or other treatment options [10][11][12]. In fact, repeat hepatectomy has been associated with improved outcomes with a 32% increased odds of long-term survival versus nonoperative treatment options 21.…”

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confidence: 99%

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The impact of recurrence timing and tumor burden score on overall survival among patients undergoing repeat hepatectomy for colorectal liver metastases

Endo

Rueda

Woldesenbet

et al. 2023

Journal of Surgical Oncology

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IntroductionApproximately 15% of patients experience a resectable intrahepatic recurrence after an index curative‐intent hepatectomy for colorectal liver metastases (CRLM). We sought to investigate the impact of recurrence timing and tumor burden score (TBS) at the time of recurrence on overall survival among patients undergoing repeat hepatectomy.MethodsPatients with CRLM who experienced recurrent intrahepatic disease after initial hepatectomy between 2000 and 2020 were identified from an international multi‐institutional database. The impact of time–TBS, defined as TBS divided by the time interval of recurrence, was assessed relative to overall survival.ResultsAmong 220 patients, the median age was 60.9 years (interquartile range [IQR]: 53.0–69.0), and 144 (65.5%) patients were male. Most patients experienced multiple recurrences (n = 120, 54.5%) within 12 months after the initial hepatectomy (n = 139, 63.2%). The median tumor size of the recurrent CRLM was 2.2 cm (IQR: 1.5–3.0 cm) with a median TBS of 3.5 (2.3–4.9) at the time of recurrence. Overall, 121 (55.0%) patients underwent repeat hepatectomy, whereas 99 (45.0%) individuals were treated with systemic chemotherapy or other nonsurgical treatments; repeat hepatectomy was associated with better postrecurrence survival (PRS) (p < 0.001). Three‐year PRS incrementally worsened (low time–TBS: 71.7%, 95% confidence interval [CI], 57.9‐88.8 vs. medium: 63.6%, 95% CI, 47.7–84.8 vs. high: 49.2%, 95% CI, 31.1–77.7, p = 0.02) as time–TBS values increased. Each unit increase in time–TBS score was independently associated with a 41% higher possibility of death (hazard ratio: 1.41; 95% CI, 1.04–1.90, p = 0.03).ConclusionsTime–TBS was associated with long‐term outcomes after repeat hepatectomy for recurrent CRLM. Time–TBS may be an easy tool to help select patients who may benefit the most from repeat hepatic resection of recurrent CRLM.

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An exploration of radiological signs in post-intervention liver complications

Khorasanizadeh,

Azizi,

Cannella

et al. 2024

European Journal of Radiology

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Hepatectomy is associated with improved oncologic outcomes in recurrent colorectal liver metastases: A propensity-matched analysis

Cited by 10 publications

References 28 publications

Update on the Applications of Radiomics in Diagnosis, Staging, and Recurrence of Intrahepatic Cholangiocarcinoma

Update on the Applications of Radiomics in Diagnosis, Staging, and Recurrence of Intrahepatic Cholangiocarcinoma

The impact of recurrence timing and tumor burden score on overall survival among patients undergoing repeat hepatectomy for colorectal liver metastases

An exploration of radiological signs in post-intervention liver complications

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