Hepatectomy for malignancy in the aged population: a comparative study

Gryspeerdt, F.; Vandenbroucke-Menu, F.; Lapointe, Réal; Turcotte, Simon; Dagenais, Michel; Plasse, M.; Létourneau, Richard; Roy, Asitava Deb

doi:10.1016/j.hpb.2019.03.172

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“…We previously reported that hepatectomies are safe in older patients and don't cause higher postoperative mortality when compared to younger patients. However, older patients were prone to have one or more postoperative complications, especially infectious, when compared to younger patients [12]. Other reports showed that first and repeated resection of liver metastases can be safely performed in older patients [22][23][24].…”

Section: Discussionmentioning

confidence: 99%

“…Many physicians are reluctant to carry a curative approach in older patients, taking into consideration the associated morbidities and early mortality. Our group previously reported that hepatectomies in older patients did not have a higher 90-days mortality rate when compared to younger patients, though it carried higher risk of complications [12]. We aimed to report our center's experience and survival analysis of older patients with CRLM who underwent curative liver resection.…”

Section: Introductionmentioning

confidence: 96%

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Outcomes of Older Patients with Resectable Colorectal Liver Metastases Cancer (CRLM): Single Center Experience

et al. 2021

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Surgery is the only potential curative option of CRLM if resectable. The curative approach in patients over 70 years old is challenging mainly because of comorbidities and other geriatric syndromes. Herein, we report outcomes of older patients with resectable CRLM in our center. We retrospectively analyzed characteristics and outcomes of older patients with CRLM operated at “Centre Hospitalier de l’Université de Montréal” (CHUM) between 2010 and 2019. We identified 210 patients aged ≥70 years with a median age of 76 (range: 70–85). CRLM were synchronous in 56% of patients. Median disease-free survival (DFS) was 41.3 months. Median overall survival (OS) was 62.2 months and estimated 5-year survival rate was 51.5% similar to those of younger counterparts. Patients with metachronous CRLM had a trend to a higher OS compared to those with synchronous disease (67.2 vs. 58.7 months; p = 0.42). Factors associated with lower survival in the multivariate analysis were right-sided tumors and increased Charlson Comorbidity index (CCI). Survival outcomes of patients aged ≥70 years were comparable to those of younger patients and those reported in the literature. Age should not be a limiting factor in the curative management of older patients with resectable CRLM.

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