Héparinothérapie : une alternative à la plasmaphérèse au décours de la pancréatite aiguë hyperlipidémique gravidique. À propos d'un cas

Sleth, Jean-Christian; Lafforgue, E.; Servais, R; Saizy, C.; Pluskwa, F.; Huet, D. Garrigue; Benamran, S.; Vérin, C.

doi:10.1016/j.annfar.2004.06.006

Cited by 36 publications

(6 citation statements)

References 10 publications

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“…6 Insulin and heparin stimulate lipoprotein lipase activity which is functioned as clearence of triglyceride from the plasma. 7 Also plasmapheresis is an effective alternative to decrease high triglyceride levels and risk of maternal and fetal mortality. [8][9][10] Acute pancreatitis itself or associated preeclampsia-eclampsia or HELLP syndrome lead to fetal and maternal death.…”

Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy

Çelik¹,

ÇELİK²,

DİKMEN³

et al. 2018

JCOG

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: 26 cute pancreatitis is a sudden inflammation of the pancreas. It is related with severe complications and high mortality despite treatment. One of the most common causes of acute pancreatitis is hypertriglyceridemia (HTG). Hypertriglyceridemia is defined as triglyceride levels more than 150 mg/dl. In normal pregnancy, lipid profile can change in response to estrogen levels. But it is important to distinguish normal from abnormal rise. There are effective treatment choices during pregnancy such as dietary restriction of fat, intravenous heparin and insulin and plasmapheresis. CASE REPORTThe patient was admitted with epigastric pain, nausea and hypertension in the 31 st weeks of gestation. Fetal heart beats were present. On admission, her vital signs were normal except blood pressure which was 150/100 mmHg. She had diabetes mellitus and hepatosplenomegaly in history. Her liver function tests had increased occasionally during pregnancy. Cesarean delivery was performed and a 1375-g female infant was delivered with 1-minute Apgar score 7 and 5-minute Apgar score 9. Her laboratory studies showed hematocrit 30.6% (normal range 35-45%), white blood cell count 19.900 cells/µL (normal range 3700-10.000 cells/L), triglyceride 1108 mg/dL (normal range <150 mg/dL), amylase 252 U/L (normal range <100 U/L), lipase 1146 U/L (normal range <60 U/L), lactate dehydrogenase 3954 U/L (normal range <448 U/L) and slightly elevated liver and renal function tests. Hypertriglyceridemia-Induced Acute Pancreatitis During PregnancyA AB BS S T TR RA AC CT T Acute pancreatitis is a sudden inflammation of the pancreas. It is related with severe complications and high mortality despite treatment. One of the most common causes of acute pancreatitis is hypertriglyceridemia (HTG) that is defined as triglyceride levels more than 150 mg/dl. There are effective treatment choices during pregnancy such as dietary restriction of fat, intravenous heparin and insulin and plasmapheresis. We presented a patient with severe HTG induced pancreatitis during pregnancy. She was consulted with hypertension and epigastric pain in the 31st weeks of gestation. After birth, she was treated successfully with heparin, insulin and cessation of oral intake and total parenteral nutrition.K Ke ey yw wo or rd ds s: : Pancreatitis; hypertriglyceridemia; pre-eclampsia; pregnancy

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Section: Discussionmentioning

confidence: 99%

Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy

Çelik¹,

ÇELİK²,

DİKMEN³

et al. 2018

JCOG

View full text Add to dashboard Cite

show abstract

“…Better outcomes have been noted in patients who were plasmapheresed less that 48 hours before onset of symptoms. Complete resolution of symptoms is reported after the first round of apheresis, as long the tryglyceride levels dropped below 500 mg/dL [6, 7]. …”

Section: Discussionmentioning

confidence: 99%

“…In a review of ten patients with hypertriglyceridemic pancreatitis, nine received apheresis with intravenous heparin and insulin within 48 hours of the diagnosis, with successful outcomes [6]. …”

Section: Discussionmentioning

confidence: 99%

Abdominal pain in hypertriglyceridemia

Alkimawi

2014

Gastroenterology Report

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“…Severe hypertriglyceridemia can be acutely treated with glucose insulin infusion, 6 or intravenous heparin infusion 7 as both insulin and heparin stimulate LPL activity. Whilst fibrates are not licensed for use during pregnancy, there are case reports of successful use of fenofibrate 8 or omega 3 fatty acids 9 during pregnancy resulting in favourable pregnancy outcome.…”

Section: Discussionmentioning

confidence: 99%

Héparinothérapie : une alternative à la plasmaphérèse au décours de la pancréatite aiguë hyperlipidémique gravidique. À propos d'un cas

Cited by 36 publications

References 10 publications

Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy

Hypertriglyceridemia-Induced Acute Pancreatitis During Pregnancy

Abdominal pain in hypertriglyceridemia

Hypertriglyceridemic pancreatitis in pregnancy: case reports and review of the literature

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