Heparinless Venoarterial Bypass

Heparinless venoarterial bypass (HL-VAB) was carried out in 16 sheep for 6 days, by means of a closed circuit tubing coated with nonthrombogenic polyurethane-polyvinyl-graphite (PPG) and a roller pump. Nine experiments were completed uneventfully. Seven sheep died during bypass. The causes of death were pneumonia (2), caseous granulomatous lung abscess (3) or abdominal abscess (1), and thromboembolism (1). The last complication was caused by inadverten trauma to the PPG coating at the time of tubing connection. In the animals in which HL-VAB was uneventful, no significant changes were noted in the hematologic studies including white blood counts, platelet counts, hematocrit, plasma fibrinogen levels, prothrombin time, thrombin time, activated partial thromboplastin time, Factors V and VIII, and free plasma hemoglobin levels. Inconsistant changes in the above parmeters were noted in the animals which died of complications. In conclusion, prolonged HL-VAB has no adverse effects on blood coagulation mechanism.

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Blood coagulation studies during six day heparinless venoarterial bypass in sheep

Wakabayashi

Woolley

Nakamura

et al. 1976

Journal of Surgical Oncology

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Automatic control of a seriesparallel mechanical circulatory assist system in severe uni-or biventricular failure

et al. 1980

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Heparin-coated cBypass circuits

Gravlee

1994

Journal of Cardiothoracic and Vascular Anesthesia

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Heparinless Venoarterial Bypass

Cited by 10 publications

References 12 publications

Blood coagulation studies during six day heparinless venoarterial bypass in sheep

Blood coagulation studies during six day heparinless venoarterial bypass in sheep

Automatic control of a seriesparallel mechanical circulatory assist system in severe uni-or biventricular failure

Heparin-coated cBypass circuits

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