Heparin Oligosaccharides as Vasoactive Intestinal Peptide Inhibitors via
their Binding Process Characterization
Meixin Li,
Yaqi Xue,
Lianli Chi
et al.
Abstract:Background:
It has been proven that vasoactive intestinal peptide (VIP) was involved
in the pathogenesis of prostate cancer. Cardin et al. found that by an alanine scan, the heparin-binding site on VIP was exactly the same sequence in VIP and its receptor. Therefore, heparin could
competitively block the binding of VIP and its receptor. However, the structure-activity relationship between heparin and VIP has not been reported, especially in terms of the sequence and sulfation patterns of heparin oligosaccharid… Show more
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