Heparin‐induced thrombocytopenia presenting with thrombosis of multiple saphenous vein grafts and myocardial infarction

Abstract

We report herein a patient with coronary artery disease that developed heparin-induced thrombocytopenia after coronary artery bypass graft with resulting thrombosis of multiple saphenous vein grafts and myocardial infarction after heparin exposure. The patient required lepirudin and a cardiac catheterization with placement of stents. Am.

A Rare Case of Acute Myocardial Infarction due to Coronary Artery Dissection and Heparin-Induced Thrombocytopenia

“…The site of thrombosis is influenced by multiple factors; areas of vascular injury and endothelial dysfunction are the most likely sites [9]. Although myocardial infarction is a rare complication of HIT, the risk is significantly increased when the integrity of the vascular endothelium has been compromised; this is most often seen in coronary bypass grafts, although disrupted native coronary vessels are also at risk [9, 10, 13]. Acute treatment includes discontinuation of all heparin products, the initiation of a direct thrombin inhibitor such as argatroban, and bridging to warfarin, regardless of clinically-apparent thrombosis [9, 14].…”

Left atrial thrombosis due to heparin-induced thrombocytopenia

“…Early diagnosis and treatment for HIT is essential to prevent subsequent thromboembolic events [1][2][3][4][5].…”

Delayed-onset heparin-induced thrombocytopenia presenting with multiple arteriovenous thromboses: case report

“…The incidence of HIT in patients who have undergone cardiopulmonary bypass surgery has been estimated at 1.9% [ 1 ]. HIT causes not only thrombocytopenia but also arterial and venous thrombotic events such as lower limb ischemia, stroke, acute myocardial infarction and renal failure [ 2 , 3 ]. The time course to development of HIT is generally within 4 to 14 days after the initiation of heparin therapy.…”