Heparin-Induced Thrombocytopenia during Continuous Veno-Venous Hemodiafiltration after Total Aortic Arch Replacement: A case report

Heparin-induced thrombocytopenia (HIT) is usually caused by anti-platelet factor 4 (PF4)/heparin antibodies, leading to intravascular platelet activation. Circulating anti-PF4/heaprin antibody (IgG, IgA and IgM) was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France) in a 61-yearold man with coronary artery disease and dyspnea on exercise. He had undergone a coronoary angiography using 2,000 unit of heparin before a procedure. On admission, laboratory testing revealed a platelet count of 296×10 9 /L and aPTT (activated partial thromboplastin time) of 38.1 sec. The fall in the platelet count was progressive, resulting in 42% and 53% of platelet counts on the 6th and 12th days after intravenous heparin administration, respectively. He was discharged after coronary artery bypass graft. On discharge, platelet count was normalized to be 212×10 9 /L. On the 7th day after dischage, anti-PF4/heaprin antibody was detected by ELISA (Asserachrom HPIA, Diagnostia Stago, Asnieres, France).

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Heparin-Induced Thrombocytopenia during Continuous Veno-Venous Hemodiafiltration after Total Aortic Arch Replacement: A case report

Cited by 2 publications

References 13 publications

Two Cases of Heparin-Induced Thrombocytopenia Diagnosed by Particle Gel Immunoassay

Two Cases of Heparin-Induced Thrombocytopenia Diagnosed by Particle Gel Immunoassay

A Case of Heparin Induced Thrombocytopenia with Circulating Anti-PF4/Heparin Antibody

Contact Info

Product

Resources

About