“…Protein C use also has been reported to prevent vascular thrombosis in a patient with familial protein C deficiency undergoing renal transplantation [28]. Ceprotin 1 has an excellent safety profile: no reported medication interactions, overdose, blood-borne infections, bleeding, or prothrombotic complications [6,9,14,23,25,26]. Given our patient's personal and family history of idiopathic PE, the presence of two thrombophilic mutations, and the substantial thrombotic and bleeding risks posed by THA [21], we decided the off-label use of protein C concentrate represented the most efficacious approach.…”