Heparin-induced priapism

Bschleipfer, T.; Ew, Hauck; Diemer, T.; Bitzer, Michael; Kirkpatrick, Charles James; Pust, R; Weidner, W.

doi:10.1038/sj.ijir.3900759

Cited by 28 publications

(12 citation statements)

References 9 publications

(22 reference statements)

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“…Patients with Fabry's disease (glycosphingolipid lipidosis) present with a combination of renal insufficiency and priapism. Priapism can also result from a high concentration (ie, 20% vs 10%) of fat emulsion in total parenteral nutrition, or with paradoxic thromboembolic events associated with heparin or warfarin use [18][19][20][21][22]. Additionally, androgens have been implicated as an important etiologic factor.…”

Section: Etiology and Epidemiologymentioning

confidence: 96%

The etiology, diagnosis, and treatment of priapism: Review of the American Foundation for Urologic Disease Consensus Panel report

Sadeghi‐Nejad¹,

Seftel

2002

Curr Urol Rep

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Priapism is an important medical condition that requires immediate evaluation, and depending on etiology, may require emergency management. Based on the classification scheme offered by a recent consensus panel, priapism can be subdivided into ischemic and nonischemic types. The nonischemic type, usually the result of perineal trauma, can be treated with conservative therapy, whereas the nonischemic type, which arises from many varied causes, mandates immediate intervention. Corporal fibrosis and permanent erectile dysfunction can result from ischemic priapism that fails to resolve with therapy.

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Section: Etiology and Epidemiologymentioning

confidence: 96%

The etiology, diagnosis, and treatment of priapism: Review of the American Foundation for Urologic Disease Consensus Panel report

Sadeghi‐Nejad¹,

Seftel

2002

Curr Urol Rep

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“…The pathophysiological mechanism of priapism following use of heparin is that it induces the development of antiplatelet-antibodies that may lead to the aggregation of thrombocytes and thus alter the penile blood flow leading to low-flow priapism 11. Also, heparin when stopped abruptly results in rebound hypercoaguable state resulting thrombosis of corpora cavernosa as well as corpus spongiosum 12…”

Section: Discussionmentioning

confidence: 99%

Anticoagulant-induced priapism progressing to penile gangrene: a devastating complication!

et al. 2012

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SummaryA 35-year-old man developed priapism with the use of low-molecular-weight heparin and warfarin following repair of left brachial artery sustained after gunshot injury. Priapism progressed to penile gangrene despite decompression and distal shunt procedure leading to total penectomy and perineal urethrostomy. We describe the mechanism of anticoagulant (heparin and warfarin)-induced penile gangrene and the possible methods to avert such a devastating complication. BACKGROUND

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“…Furthermore, heparin‐induced antiplatelet antibodies may lead to an aggregation of thrombocytes and thus alter the penile blood flow leading to low‐flow priapism. Alternatively, this condition may be explained by initial high‐flow priapism that later turns into ischaemic priapism (Bschleipfer et al. , 2001).…”

Section: Discussionmentioning

confidence: 99%