Heparin–collagen I bilayers stimulate FAK/ERK½ signaling via α2β1 integrin to support the growth and anti‐inflammatory potency of mesenchymal stromal cells
Said J. Cifuentes,
Maribella Domenech
Abstract:Understanding mesenchymal stromal cells (MSCs) growth mechanisms in response to surface chemistries is essential to optimize culture methods for high‐quality and robust cell yields in cell manufacturing applications. Heparin (HEP) and collagen 1 (COL) substrates have been reported to enhance cell adhesion, growth, viability, and secretory potential in MSCs. However, the biomolecular mechanisms underlying the benefits of combined HEP/COL substrates are unknown. This work used HEP/COL bilayered surfaces to inves… Show more
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