Heparin-bonded expanded polytetrafluoroethylene femoropopliteal bypass grafts outperform expanded polytetrafluoroethylene grafts without heparin in a long-term comparison

Samson, Russell H.; Morales, Ricardo; Showalter, David P.; Lepore, Michael R.; Nair, Deepak G.

doi:10.1016/j.jvs.2016.03.414

Cited by 57 publications

(35 citation statements)

References 32 publications

(35 reference statements)

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“…3), which were the antisymmetric and symmetric stretching vibration absorption peaks of CF 2 , respectively. Consistent peaks at 2300-2400 cm 21 were observed in the spectrum of heparin as well as the spectra of the modified ePTFE films. In addition, the characteristic peaks at 1024 cm 21 were attributed to the symmetric vibrational band of the sulfonic groups (AOSO 3 A) in heparin.…”

Section: Successful Construction Of Hep/col Multilayers and Immobilizsupporting

confidence: 64%

“…In addition, the characteristic peaks at 1024 cm 21 were attributed to the symmetric vibrational band of the sulfonic groups (AOSO 3 A) in heparin. Characteristic absorption peaks of the amide I band were observed at approximately 1653 cm 21 . Distinctive peaks, attributed to the NAH bending and CAN stretching vibrations of amide II, were observed at approximately 1558 cm 21 , suggesting that the assembled collagen retained its triple-helical structure.…”

Section: Successful Construction Of Hep/col Multilayers and Immobilizmentioning

confidence: 99%

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Application of Heparin/Collagen‐REDV Selective Active Interface on ePTFE Films to Enhance Endothelialization and Anticoagulation

Shan

Jia

et al. 2018

Artificial Organs

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Expanded polytetrafluoroethylene (ePTFE) prosthetic valves have been widely used in clinical applications in Asian countries. However, these valves still have limits with regard to thrombosis, neointimal hyperplasia, restenosis, and valvar vegetation. The achievement of in situ endothelialization on implant materials is a promising way to overcome those limits. Here, heparin/collagen multilayers were fabricated on ePTFE films via a layer-by-layer (LBL) self-assembly technique, and then, the endothelial cell (EC) adhesive peptide sequence Arg-Glu-Asp-Val (REDV) was immobilized on the multilayers. After modification with the heparin/collagen multilayers with or without REDV peptide, less platelet activation and aggregation were observed, the blood coagulation time was increased, and the hemolysis rate was decreased compared to that on pristine ePTFE films. The REDV-functionalized ePTFE films positively impacted early EC adhesion, later cell proliferation and cell activity. The EC barrier was confirmed to be successfully achieved on the functionalized ePTFE film surface in vitro. The successful assembly of the REDV-functionalized heparin/collagen multilayer on ePTFE films improved the blood compatibility, anticoagulant properties, and cell compatibility of the films in vitro, and thus, represents a candidate approach for applications requiring quick in situ endothelialization in vivo.

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Section: Successful Construction Of Hep/col Multilayers and Immobilizsupporting

confidence: 64%

Section: Successful Construction Of Hep/col Multilayers and Immobilizmentioning

confidence: 99%

Application of Heparin/Collagen‐REDV Selective Active Interface on ePTFE Films to Enhance Endothelialization and Anticoagulation

Shan

Jia

et al. 2018

Artificial Organs

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“…Karen et al 4 reported a comparable 4 year primary patency between covered stent endograft and expanded politretrafluoroethylene (ePTFE) bypass graft (59% vs 58%; p=.807) for the treatment of SFA obstructive lesions > 25 cm in length. More recently, Samson 16 reported a primary patency of 74.5% at 5 years for new generation heparin-bonded ePTFE bypass, increasing to 85% when above the knee bypass was performed.…”

Section: Discussionmentioning

confidence: 99%

Iliac Artery Stenting Combined with Ipsilateral Open Femoro-Popliteal Revascularization and Its Effect on Bypass Patency

Piazza

Squizzato

Lepidi

et al. 2017

Annals of Vascular Surgery

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“…12) When performing femoropopliteal bypass surgeries, heparinbonded ePTFE grafts showed significantly better graft patency rates than non-heparin-bonded ePTFE grafts. 13) However, no report has compared the graft patency rates between heparin-bonded and non-heparin-bonded ePTFE grafts in AxFB. Furthermore, Samson et al 7) reported that 2 of 34 (5.9%) non-heparin-bonded ePTFE grafts and 3 of 42 (7.1%) heparin-bonded ePTFE grafts were thrombosed; therefore, they concluded that they could not demonstrate the superiority of heparin-bonded ePTFE grafts for AxFB.…”

Section: Discussionmentioning

confidence: 99%

The Comparison between Axillofemoral Bypass and Endovascular Treatment for Patients with Challenging Aortoiliac Occlusive Disease as Alternative Treatment to Aortofemoral Bypass

Nishizawa

Igari

Katsui

et al. 2020

Annals of Vascular Diseases

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Objective: Although aortofemoral bypass (AoFB) is the standard treatment for challenging aortoiliac occlusive disease (AIOD), less-invasive treatments, such as axillofemoral bypass (AxFB) or endovascular treatment (EVT) have been conducted for patients with severe comorbidities. In this study, we compared the clinical outcomes between AxFB and EVT for AIOD. Materials and Methods: We retrospectively reviewed 9 patients with AxFB and 10 with EVT for challenging AIOD. The patients information and operative results were evaluated. The rates of patency and limb salvage were analyzed according to the Kaplan-Meier method. Results: In the EVT group, 5 of 10 (50%) patients had aortic stenting alone, 3 (30%) received aorto-uniiliac stenting, and 2 (20%) received aorto-biiliac stenting. In the AxFB group, 2 cases (22.2%) showed acute graft thrombosis; however, in the EVT group, no acute thrombotic complications were seen. The primary patency rates in the AxFB and EVT groups at 5 years were 53.6% and 81.2%, respectively (log rank P=0.225), and the assisted primary patency rates at 5 years were 53.6% and 100%, respectively (log rank P=0.012). Conclusion: EVT exhibited a more durable, better longterm patency rate than AxFB. EVT may, therefore, be a viable treatment alternative to AoFB for challenging AIOD.

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Heparin-bonded expanded polytetrafluoroethylene femoropopliteal bypass grafts outperform expanded polytetrafluoroethylene grafts without heparin in a long-term comparison

Abstract: These data show that the Propaten HePTFE graft offered significantly better long-term patency over the SePTFE graft, suggesting Propaten as the prosthetic graft of choice for bypasses to the femoropopliteal artery when autologous vein is unavailable or inappropriate.

Cited by 57 publications

References 32 publications

Application of Heparin/Collagen‐REDV Selective Active Interface on ePTFE Films to Enhance Endothelialization and Anticoagulation

Application of Heparin/Collagen‐REDV Selective Active Interface on ePTFE Films to Enhance Endothelialization and Anticoagulation

Iliac Artery Stenting Combined with Ipsilateral Open Femoro-Popliteal Revascularization and Its Effect on Bypass Patency

The Comparison between Axillofemoral Bypass and Endovascular Treatment for Patients with Challenging Aortoiliac Occlusive Disease as Alternative Treatment to Aortofemoral Bypass

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