Heparin-Binding Protein Levels at Admission and Within 24 h Are Associated with Persistent Organ Failure in Acute Pancreatitis

Shu, Wenqing; Wan, Jianhua; Yang, Xiaoyu; Chen, Jie; Yang, Qingping; Liu, Fen; Xia, Liang

doi:10.1007/s10620-020-06660-1

Cited by 7 publications

(9 citation statements)

References 28 publications

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“…We found that in SAP group, the PCT, HBP, and IL‐6 values measured on day 1 were significantly higher than those measured on day 10 (42.24 ng/ml, 134 ng/ml, and 552.3 pg/ml vs 4.74 ng/ml, 64.99 ng/ml, and 91.92 pg/ml, respectively). Based on our statistical results, early monitoring of three biomarkers plays an important role in the diagnosis of AP, which is consistent with the related reports 17,25 …”

Section: Discussionsupporting

confidence: 92%

“…Some studies have also confirmed the potential value of IL‐6 as a prognostic indicator in SAP 30,31 . However, to the best of our knowledge, to date, only 1 study published in 2020 has reported the use of HBP to predict persistent organ failure in AP patients with a specificity of 74%, a sensitivity of 90%, and an AUC of 0.82 25 . Our study revealed that the concentrations of analyzed biomarkers were all significantly higher in deaths than in survivors, suggesting that elevated levels were important risk factors for the development of AP.…”

Section: Discussionmentioning

confidence: 92%

“…Infection is an important factor affecting the course and prognosis of SAP patients. The mortality rate of sepsis and multiple organ failure caused by secondary pancreatic and peripancreatic infection is as high as 50% 25 . Semmlack S' study suggested that APACHE II scoring system, which was based only on acute physiology and health assessments, was less effective in assessing complications 28 .…”

Section: Discussionmentioning

confidence: 99%

“…Based on our statistical results, early monitoring of three biomarkers plays an important role in the diagnosis of AP, which is consistent with the related reports. 17 , 25 …”

Section: Discussionmentioning

confidence: 99%

“…The mortality rate of sepsis and multiple organ failure caused by secondary pancreatic and peripancreatic infection is as high as 50%. 25 Semmlack S' study suggested that APACHE II scoring system, which was based only on acute physiology and health assessments, was less effective in assessing complications. 28 A multicenter trial revealed that at a PCT value of 3.8 ng/ml within 96 h after the onset of symptoms, diagnostic sensitivity and specificity for pancreatic necrosis or death were 93% and 79%, respectively.…”

Section: Discussionmentioning

confidence: 99%

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Combined detection of procalcitonin, heparin‐binding protein, and interleukin‐6 is a promising assay to diagnose and predict acute pancreatitis

Zhong

Wang

et al. 2021

Clinical Laboratory Analysis

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Background Acute pancreatitis (AP), one of the most common clinical emergencies, is characterized by variable clinical features and inadequate diagnostic methods. At present, the commonly used indicators do not have high specificity and do not necessarily reflect disease severity. We therefore aimed to investigate diagnostic and prognostic value of plasma procalcitonin, heparin‐binding protein, and interleukin‐6 for acute pancreatitis by separate detection and joint detection. Methods The study involved 451 participants, including 343 AP patients and 108 healthy controls. We analyzed the association of the three biomarkers with the severity and prognosis of AP. Results A statistically significant increase in the mean plasma analyte levels was detected in the study group compared to the control group. Multivariate comparison showed that plasma levels of PCT, HBP, and IL‐6 were all significantly different among the three groups at different sampling times (1st, 3rd, 7th, and 10th day of admission) (p < 0.01). The combination of the three indicators had significantly higher diagnostic value than either the individual markers or pairwise combinations (p < 0.001). The levels of the three were all significantly higher in severe acute pancreatitis (SAP) patients than in non‐SAP patients (p < 0.001); meanwhile, patients with high levels had a worse prognosis than those with low levels (p < 0.05). In multivariate analysis adjusted for age and sex, high levels of PCT, HBP, and IL‐6 were found to be independently associated with the development of AP. Conclusions It dramatically improved the diagnostic power of AP when PCT, HBP, and IL‐6 were combined; high PCT, HBP, and IL‐6 levels within 3 days of admission may be the potentially useful indicators for predicting SAP.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 92%

Section: Discussionmentioning

confidence: 99%

“…Based on our statistical results, early monitoring of three biomarkers plays an important role in the diagnosis of AP, which is consistent with the related reports. 17 , 25 …”

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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