“…Most of its distribution shortly after administration is within the plasma, liver, kidneys, bile, and urine. (Feng et al, 2006, Yang et al, 2014) The rapid decline of HB-EGF in plasma is dues to a rapid irreversible uptake process. (Burwen et al, 1985, Dunn and Hubbard, 1984, Kim et al, 1988, St Hilaire et al, 1983)Given its rapid distribution and elimination, it is not surprising that the small doses used in our study, even if delivered intravenously, cannot be detected above background levels.…”