Heparin-Based Hydrogel Micropatches with Human Adipose-Derived Stem Cells: A Promising Therapeutic Approach for Neuropathic Pain Relief

Abstract

This study explores the therapeutic efficacy of heparin-based hydrogel micropatches containing human adipose-derived stem cells (hASCs) in treating neuropathic pain caused by nerve damage. Our results showed that hASCs exhibited neuroregenerative and pain-relieving effects when used with heparin-based hydrogel micropatches in the neuropathic pain animal model. The use of this combination also produced enhanced cell viability and nerve regeneration. We conducted various neurological behavioral tests, dynamic plantar tests, histological examinations, and neuroelectrophysiological examinations to confirm the therapeutic effect. Our findings suggest that this approach could maximize therapeutic efficacy and improve the quality of life for patients suffering from neuropathic pain.

Optimization strategies for mesenchymal stem cell-based analgesia therapy: a promising therapy for pain management

“…The heparin-based hydrogel micropatches can promote the proliferation and maintain the stemness of hAD-MSCs in vitro. Furthermore, they can improve the survival rate and retention rate of hAD-MSCs in injured nerve tissue, and enhance the therapeutic effect of hAD-MSCs in nerve repair and pain relief [ 79 ].…”

A multi-channel collagen conduit with aligned Schwann cells and endothelial cells for enhanced neuronal regeneration in spinal cord injury

“…We have previously reported that the paracrine effect of transplanted cells causes SCI recovery. [35][36][37][38] Although the transplanted cells do not survive for up to eight weeks, the embedded SCs secrete cytokines, exosomes, and paracrine factors, while the ECs secrete neurotransmitters that induce axonal regeneration. 39,40 In addition, we have demonstrated that the hydrogel is an excellent material for the treatment of neurodegeneration and results in behavioral improvement after SCI.…”