Heparin as a molecular spacer immobilized on microspheres to improve blood compatibility in hemoperfusion

Dang, Qi; Li, Chun-Gong; Jin, Xinxin; Zhao, Yajin; Wang, Xiang

doi:10.1016/j.carbpol.2018.08.067

Cited by 32 publications

(8 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The absorbance values of the sample (ODs) were substituted into the formula specified in the Methods to calculate the hemolysis rate. The hemolysis rate of the membrane surface was <5%, consistent with the standard for medical polymer materials, and the multilayer structure fulfilled the requirements of the body environment (Dang et al, 2019).…”

Section: In Vitro Hemolysis Ratesupporting

confidence: 73%

Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment

Bai

Xiao

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

Bone implant-associated infection is one of the most challenging problems encountered by orthopedic surgeons. There is considerable interest in the development of drug-loaded antibacterial coatings for the surfaces of metal implants. However, it is difficult to achieve the stable local release of an effective drug dose for many antibacterial coatings. In the present study, analyses of the thickness and water contact angle of multiple layers confirmed the successful assembly of multilamellar membrane structures. Measurement of the zone of bacterial inhibition indicated gradual degradation of the (montmorillonite [MMT]/hyaluronic acid [HA])10 multilamellar film structure with concentration-dependent degradation during incubation with hyaluronidase solution and Staphylococcus aureus. In vivo results resembled the in vitro results. Overall, the findings confirm that the (MMT/HA-rifampicin)10 multilamellar film structure exhibits good antibacterial properties and excellent biocompatibility. Further studies of the clinical potential of the antibacterial coating prepared in this experiment are warranted.

show abstract

Section: In Vitro Hemolysis Ratesupporting

confidence: 73%

Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment

Bai

Xiao

et al. 2023

Front. Bioeng. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Apart from natural ligands, several synthetic materials have also been developed. Poly(1-vinylimidazole), allantoin crystals, chitosan, − poly-ε-caprolactone, imidazolium-type polyurethane, and amino acids − have been reported for LPS clearance. Unfortunately, although these synthetic materials exhibited LPS clearance capability to a certain extent, they generally suffer from poor selectivity toward LPSs when it comes to complicated biosamples, severely limiting their further applications in blood purification.…”

Section: Introductionmentioning

confidence: 99%

Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer

Chen,

Shi,

Yang

et al. 2023

ACS Appl. Mater. Interfaces

View full text Add to dashboard Cite

Blood infection can release toxic bacterial lipopolysaccharides (LPSs) into bloodstream, trigger a series of inflammatory reactions, and eventually lead to multiple organ dysfunction, irreversible shock, and even death, which seriously threatens human life and health. Herein, a functional block copolymer with excellent hemocompatibility is proposed to enable broad-spectrum clearance of LPSs from whole blood blindly before pathogen identification, facilitating timely rescue from sepsis. A dipeptide ligand of histidine–histidine (HH) was designed as the LPS binding unit, and poly[(trimethylamine N-oxide)-co-(histidine–histidine)], a functional block copolymer combining the LPS ligand of HH and a zwitterionic antifouling unit of trimethylamine N-oxide (TMAO), was then designed by reversible addition–fragmentation chain transfer (RAFT) polymerization. The functional polymer achieved effective clearance of LPSs from solutions and whole blood in a broad-spectrum manner and had good antifouling and anti-interference properties and hemocompatibility. The proposed functional dihistidine polymer provides a novel strategy for achieving broad-spectrum clearance of LPSs, with potential applications in clinical blood purification.

show abstract

“…After 200 cycles of compression at 70% strain, it recovered its original shape without cracking (Supporting Video S1), and the as-prepared monolith showed more favorable mechanical properties than a polysaccharide-based composite aerogel. 35,36 This mechanical feature was conducive to its application in HP.…”

Section: = ×mentioning

confidence: 98%

Heparin-Mimetic Chitooligosaccharides-Based Monoliths Obtained from C/W Emulsions: Hemocompatibility and Toxin Removal Ability

Xu,

Cao,

Wang

et al. 2023

ACS Biomater. Sci. Eng.

View full text Add to dashboard Cite

Heparin as a molecular spacer immobilized on microspheres to improve blood compatibility in hemoperfusion

Cited by 32 publications

References 43 publications

Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment

Antibacterial intraosseous implant surface coating that responds to changes in the bacterial microenvironment

Broad-Spectrum Clearance of Lipopolysaccharides from Blood Based on a Hemocompatible Dihistidine Polymer

Heparin-Mimetic Chitooligosaccharides-Based Monoliths Obtained from C/W Emulsions: Hemocompatibility and Toxin Removal Ability

Contact Info

Product

Resources

About