Heparanized chitosans: towards the third generation of chitinous biomaterials

Revuelta, Julia; Fraile, Isabel; Monterrey, Dianelis T.; Peña, Nerea; Benito-Arenas, Raúl; Bastida, Ágatha; Fernández-Mayoralas, Alfonso; García‐Junceda, Eduardo

doi:10.1039/d1mh00728a

Cited by 16 publications

(7 citation statements)

References 141 publications

(159 reference statements)

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“…118 Besides, functionalizing CS structures through chemical modifications to achieve better properties, such as anti-oxidant, anti-bacterial, anti-allergy, anti-hypertensive, and immunology regulation performance, has become a research hotspot in the biomedical field. 119,120 Nowadays, common CS derivatives mainly include sulfated chitosan (SCS), carboxymethyl chitosan (CCS), phosphorylated chitosan (PCS) and quaternized chitosan (QCS). 121 SCS is generally produced by the treatment of CS with chlorosulfonic acid, and the composite nanofibers formed by SCS/PCL were found to effectively promote the deposition of calcium apatite and enhance the adhesion capacity of osteoblasts.…”

Section: Electrospun Nanofibers For Bone Regenerationmentioning

confidence: 99%

Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

et al. 2022

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Section: Electrospun Nanofibers For Bone Regenerationmentioning

confidence: 99%

Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

et al. 2022

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“…Several reactions can be performed on the hydroxyl groups ( Scheme 4 ), including etherification and acylation ( Scheme 4 a,b and 4c, respectively) [ 64 ], azidation ( Scheme 4 d) [ 65 ], sulfation and sulfonation ( Scheme 4 e) [ 66 ], phosphorylation ( Scheme 4 f) [ 67 ].…”

Section: Chitosan Functionalities: Friend or Foe?mentioning

confidence: 99%

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

et al. 2023

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Chitosan is a marine-origin polysaccharide obtained from the deacetylation of chitin, the main component of crustaceans’ exoskeleton, and the second most abundant in nature. Although this biopolymer has received limited attention for several decades right after its discovery, since the new millennium chitosan has emerged owing to its physicochemical, structural and biological properties, multifunctionalities and applications in several sectors. This review aims at providing an overview of chitosan properties, chemical functionalization, and the innovative biomaterials obtained thereof. Firstly, the chemical functionalization of chitosan backbone in the amino and hydroxyl groups will be addressed. Then, the review will focus on the bottom-up strategies to process a wide array of chitosan-based biomaterials. In particular, the preparation of chitosan-based hydrogels, organic–inorganic hybrids, layer-by-layer assemblies, (bio)inks and their use in the biomedical field will be covered aiming to elucidate and inspire the community to keep on exploring the unique features and properties imparted by chitosan to develop advanced biomedical devices. Given the wide body of literature that has appeared in past years, this review is far from being exhaustive. Selected works in the last 10 years will be considered.

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“…Sulfated CS derivatives have a similar ability to bind with different growth factors and other proteins, enhancing or inhibiting the binding to their receptors. [ 200 ]. GAGs can interact with various proteins in the extracellular matrix, thus signaling to mediate various cellular processes, such as adhesion, migration, proliferation, and differentiation [ 201 , 202 ].…”

Section: Cs-based Dosage Forms and Drug Delivery Systems For Antiviralsmentioning

confidence: 99%

Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers

Dominika

Mikušová

Mikuš

2023

Viruses

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Current antiviral therapy research is focused on developing dosage forms that enable highly effective drug delivery, providing a selective effect in the organism, lower risk of adverse effects, a lower dose of active pharmaceutical ingredients, and minimal toxicity. In this article, antiviral drugs and the mechanisms of their action are summarized at the beginning as a prerequisite background to develop relevant drug delivery/carrier systems for them, classified and briefly discussed subsequently. Many of the recent studies aim at different types of synthetic, semisynthetic, and natural polymers serving as a favorable matrix for the antiviral drug carrier. Besides a wider view of different antiviral delivery systems, this review focuses on advances in antiviral drug delivery systems based on chitosan (CS) and derivatized CS carriers. CS and its derivatives are evaluated concerning methods of their preparation, their basic characteristics and properties, approaches to the incorporation of an antiviral drug in the CS polymer as well as CS nanoparticulate systems, and their recent biomedical applications in the context of actual antiviral therapy. The degree of development (i.e., research study, in vitro/ex vivo/in vivo preclinical testing), as well as benefits and limitations of CS polymer and CS nanoparticulate drug delivery systems, are reported for particular viral diseases and corresponding antivirotics.

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Heparanized chitosans: towards the third generation of chitinous biomaterials

Abstract: The functionalization of chitosans is an emerging research area in the design of solutions for a wide range of biomedical applications. In particular, the modification of chitosans to incorporate sulfate...

Cited by 16 publications

References 141 publications

Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

Electrospun nanofibers for bone regeneration: from biomimetic composition, structure to function

Chitosan-Based Biomaterials: Insights into Chemistry, Properties, Devices, and Their Biomedical Applications

Advances in Antiviral Delivery Systems and Chitosan-Based Polymeric and Nanoparticulate Antivirals and Antiviral Carriers

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