“…While CPG3 results in being overexpressed in liver cancer, lung squamous cell carcinoma, neuroblastoma, ovarian cancer, testicular germ cell tumor, thyroid cancer, yolk sac tumor and other cancers, reduced levels of GPC3 have been found in breast cancer, colorectal cancer, mesothelioma, non-small-cell lung cancer, neuroblastoma, and renal cell carcinoma [35,105,[125][126][127][128][129][130]. Overexpression of GPC4 mRNA has been detected in metastatic colorectal cancer, where GPC1, GPC3 and GPC6, perlecan, and collagen type VIII result in being downregulated [31,35,105]. While GPC5 expression is downregulated in breast cancer, glioma, hepatocellular carcinoma, lung cancer, pancreatic cancer, prostate cancer, it results in being upregulated in rhabdomyosarcoma [35,[134][135][136][137][138].…”