Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation

Ferreras, Laura; Moles, Anna; Situmorang, Gerhard Reinaldi; Masri, Rana El; Wilson, Imogen L.; Cooke, Katie; Thompson, Emily; Kusche-Gullberg, Marion; Vivès, Romain R.; Sheerin, Neil; Ali, Simi

doi:10.1016/j.bbagen.2019.02.009

Cited by 11 publications

(5 citation statements)

References 80 publications

(77 reference statements)

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“…This suggests that patients with CKD have EG damage, possibly due to accumulation of uraemic toxins in the blood; this explains why the plasma perlecan level returns to its optimal range once the patients undergo TX [ 40 , 42 ]. This hypothesis is supported by the results of previous studies which demonstrated that increased release of heparinase in kidney diseases is involved in its development [ 17 ]. Heparinase degrades HS chains in low sulfidation sites, facilitating the release of perlecan into the bloodstream.…”

Section: Discussionsupporting

confidence: 78%

“…EG mainly comprises glycoproteins and proteoglycans (such as perlecan, syndecans and glypicans) [ 14 ]. Perlecan is a heparan sulfate (HS) proteoglycan that is also a component of the extracellular matrix and basal membrane [ 17 , 18 ]. Decorin, a small leucine-rich proteoglycan, is a component of the extracellular matrix and EG and is involved in regulating collagen fibril assembly, cell adhesion, angiogenesis, and modulation of growth factors and cytokine activity [ 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

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Plasma glycocalyx pattern: a mirror of endothelial damage in chronic kidney disease

Valera

Figuer

Caro

et al. 2023

Clinical Kidney Journal

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Background Endothelial damage and cardiovascular disease complicate chronic kidney disease. The increased atherogenicity observed in patients with chronic kidney disease can be linked to microinflammation and endothelial damage. Circulating endothelial glycocalyx degradation products, such as perlecan and decorin, tend to be elevated in chronic kidney disease. We aimed to explore the association between the plasma perlecan and decorin levels and this pro-inflammatory and atherogenic state by studying monocyte subpopulations and intracellular adhesion molecule (ICAM)-1 expression in patients with chronic kidney disease. Methods We studied 17 healthy controls, 23 patients with advanced chronic kidney disease, 25 patients on haemodialysis, 23 patients on peritoneal dialysis, and 20 patients who underwent kidney transplantation. Perlecan and decorin levels were evaluated using enzyme-linked immunosorbent assays, and the monocyte phenotype was analysed using direct immunofluorescence and flow cytometry. Results The plasma perlecan levels were higher in patients with chronic kidney disease than in the healthy controls. These levels were associated with a higher prevalence of ICAM-1 + monocytes. Conversely, patients with advanced chronic kidney disease (pre-dialysis) had higher plasma decorin levels, which were associated with a reduced ICAM-1 expression per monocyte. Conclusions Elevated perlecan levels in chronic kidney disease may be associated with a higher prevalence of ICAM-1 + monocytes and a pro-inflammatory phenotype. Elevated decorin levels may act as a negative regulator of ICAM-1 expression in monocytes. Therefore, perlecan and decorin may be related to inflammation and monocyte activation in chronic kidney disease and may act as potential markers of endothelial damage.

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Section: Discussionsupporting

confidence: 78%

Section: Introductionmentioning

confidence: 99%

Plasma glycocalyx pattern: a mirror of endothelial damage in chronic kidney disease

Valera

Figuer

Caro

et al. 2023

Clinical Kidney Journal

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“…Although there are currently no studies using Achatina fulica mucus in kidney disorders, the results of this study are reinforced by other studies that use components present in Achatina fulica mucus against other organ disorders, where Ferreras et al administered Heparin Binding EGF-like growth factor (HB-EGF) and proved protective in the development of liver fibrosis. Another study in wild mice treated with the small molecule antagonist HS (bis-2-methyl-4-amino-quinolyl-6carbamide, 1 mg/kg/day) for seven days after myocardial infarction provided improved heart function and survival [14,15].…”

Section: Discussionmentioning

confidence: 99%

The Effect of Snail Mucus (Achatina Fulica) on The Degree of Kidney Interstitial Fibrosis In Lupus Nephritis Mice Model

Adnan

Werdiningsih

Prabowo

et al. 2023

TSCM

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Introduction:cytotoxic drugs dominate SLE therapy, so new therapies with minimum side effects are needed. Snail (Achatina Fulica) mucus contains two types of protein; heparan and acharan sulfate. The snail mucus has significant potential benefits, but its use in lupus nephritis has never been examined.Methods:This research used an experimental model. It used mice for the experiment. The mice were divided into five groups: control, untreated lupus, standard therapy (methylprednisolone), snail mucus therapy, and a combination of standard therapy and snail mucus. Renal histology was examined at the end of the fifth month. Data were analyzed using the Shapiro-Wilk, ANOVA, and Tukey Post Hoc tests.Results: The level of interstitial fibrosis between the standard therapy group and the snail mucus group showed an MD value of -0.13 with a p-value of 1.00, meaning there is no significant difference between the level of interstitial fibrosis in the two groups. The comparison between the standard therapy group and the combination of the standard therapy group showed an MD value of 0.64 with a p-value of 0.992, which means that the combination of standard therapy tends to decrease the level of interstitial fibrosis. Conclusion: The administration of snail mucus in combination with standard therapy affects the decrease in the level of interstitial fibrosis in mice model lupus.

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“…In contrast, restricted inactivation of NDSTs to leukocytes had no effect on leukocyte infiltration (31). Changes in HS O-sulfotransferases (OSTs) expression have also been reported, during macrophage M1/M2 polarization (45), or the development of renal fibrosis (46). Interestingly, the stimulation of human monocytes by LPS or TNFα upregulates only one out of the seven 3OST isoform: 3OST3b, thus highlighting the fine tuning of sulfotransferase expression pattern during inflammation (47).…”

Section: Hs In Inflammationmentioning

confidence: 98%

HS and Inflammation: A Potential Playground for the Sulfs?

et al. 2020

Self Cite

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Heparan sulfate (HS) is a complex polysaccharide abundantly found in extracellular matrices and cell surfaces. HS participates in major cellular processes, through its ability to bind and modulate a wide array of signaling proteins. HS/ligand interactions involve saccharide domains of specific sulfation pattern. Assembly of such domains is orchestrated by a complex biosynthesis machinery and their structure is further regulated at the cell surface by post-synthetic modifying enzymes. Amongst them, extracellular sulfatases of the Sulf family catalyze the selective removal of 6-O-sulfate groups, which participate in the binding of many proteins. As such, increasing interest arose on the regulation of HS biological properties by the Sulfs. However, studies of the Sulfs have so far been essentially restricted to the fields of development and tumor progression. The aim of this review is to survey recent data of the literature on the still poorly documented role of the Sulfs during inflammation, and to widen the perspectives for the study of this intriguing regulatory mechanism toward new physiopathological processes.

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Heparan sulfate in chronic kidney diseases: Exploring the role of 3-O-sulfation

Cited by 11 publications

References 80 publications

Plasma glycocalyx pattern: a mirror of endothelial damage in chronic kidney disease

Plasma glycocalyx pattern: a mirror of endothelial damage in chronic kidney disease

The Effect of Snail Mucus (Achatina Fulica) on The Degree of Kidney Interstitial Fibrosis In Lupus Nephritis Mice Model

HS and Inflammation: A Potential Playground for the Sulfs?

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