Henoch-Schönlein purpura following influenza A H1N1 vaccination

Pimentel, Maria Inês Fernandes; Vasconcellos, Érica de Camargo Ferreira e; Cerbino-Neto, José

doi:10.1590/s0037-86822011000400029

Cited by 9 publications

(3 citation statements)

References 2 publications

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“…Genetic risk factors play an important role in the pathogenesis of the disease: it is associated with HLA-DRB*01, 07 and 11. HSP was associated with seasonal influenza, influenza A (H1N1), pneumococcal and meningococcal disease, hepatitis A virus (HAV), HBV, anti-human papilloma virus (HPV) vaccines, and following multiple combinations of vaccines, such as typhoid, cholera and yellow fever [139,[171][172][173].…”

Section: Immune Complex Small Vessels Vasculitismentioning

confidence: 99%

Vaccines, adjuvants and autoimmunity

Guimarães

Baker

Perricone

et al. 2015

Pharmacological Research

186

133

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Vaccines and autoimmunity are linked fields. Vaccine efficacy is based on whether host immune response against an antigen can elicit a memory T-cell response over time. Although the described side effects thus far have been mostly transient and acute, vaccines are able to elicit the immune system towards an autoimmune reaction. The diagnosis of a definite autoimmune disease and the occurrence of fatal outcome post-vaccination have been less frequently reported. Since vaccines are given to previously healthy hosts, who may have never developed the disease had they not been immunized, adverse events should be carefully accessed and evaluated even if they represent a limited number of occurrences. In this review of the literature, there is evidence of vaccine-induced autoimmunity and adjuvant-induced autoimmunity in both experimental models as well as human patients. Adjuvants and infectious agents may exert their immune-enhancing effects through various functional activities, encompassed by the adjuvant effect. These mechanisms are shared by different conditions triggered by adjuvants leading to the autoimmune/inflammatory syndrome induced by adjuvants (ASIA syndrome). In conclusion, there are several case reports of autoimmune diseases following vaccines, however, due to the limited number of cases, the different classifications of symptoms and the long latency period of the diseases, every attempt for an epidemiological study has so far failed to deliver a connection. Despite this, efforts to unveil the connection between the triggering of the immune system by adjuvants and the development of autoimmune conditions should be undertaken. Vaccinomics is a field that may bring to light novel customized, personalized treatment approaches in the future.

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Section: Immune Complex Small Vessels Vasculitismentioning

confidence: 99%

Vaccines, adjuvants and autoimmunity

Guimarães

Baker

Perricone

et al. 2015

Pharmacological Research

186

133

View full text Add to dashboard Cite

show abstract

“…Quase todos os artigos recuperados foram publicados após a ocorrência da pandemia de influenza pelo vírus influenza A(H1N1)pdm09 (Figura 5). Uma parte deles apresenta relatos de casos de eventos adversos raros [59][60][61][62][63][64][65][66] temporalmente associados à vacinação contra o subtipo pandêmico de 2009, tais como casos de Síndrome de Guillain-Barré, narcolepsia, paralisia oculomotora e rabdomiólise. Há também estudos transversais e de coorte, que incluíram os eventos adversos na investigação de razões para a não vacinação [67][68][69] e estudos em clientelas específicas, [70][71][72][73][74][75] além de estudos realizados entre profissionais de saúde 76 e indivíduos de 60 anos ou mais.…”

Section: Figura 4 -Estudos De Efetividade E Cobertura Vacinal Da Vaci...unclassified

Efetividade da estratégia brasileira de vacinação contra influenza: uma revisão sistemática

Luna¹,

Gattás²,

Campos³

2014

Epidemiol. Serv. Saúde

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“…Henoch-Schönlein purpura [12,13] Also known as, Schönlein-Henoch purpura. It is named for,Eduard Heinrich Henoch (1820-1910), (Fig.10), a German pediatrician, and his teacher Johann Lukas Schönlein (1793-1864), (Fig.…”

Section: Eponyms Linked To Vaccines and Its Reactions Remarksmentioning

confidence: 99%