Henoch-Schönlein purpura and crohn’s disease: Expanding the range of association in pediatric patients

Hong, John Gee; Levy, Joseph; Stokar, Evan

doi:10.1007/s12328-021-01456-w

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The study of Eon Jeong Nam et al stated that the terminal ileum is the most vulnerable, but this is based on adult reports [10] . So far, we reviewed the literatures published by PUBMED, 14 of which are IgA vasculitis with terminal ileitis (not including our 2 cases), of which only 3 literatures reported that 5 children had terminal ileitis [4,11,12]. A Chinese study on childhood IgA vasculitis showed that capsule endoscopy revealed that the jejunum was the most affected site, accounting for 96.7%, followed by the descending duodenum (33.3%), and no colon involvement was found [13].…”

Section: Casementioning

confidence: 97%

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IgA vasculitis with terminal ileitis and giant duodenum ulceration and review of the literatures

Wang

2021

Preprint

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BackgroundImmunoglobulin A vasculitis (IgA V), formerly Henoch–Schönlein purpura, is one of the most common self-limiting vasculitis in children. In 15-20% IgA V cases, gastrointestinal symptoms precede the rashes,they no specific gastrointestinal symptoms and often present as acute abdomen, making the diagnosis difficult.Case presentationWe present two female patients, ages 8 years old and 5 years old, who presented to vomiting and abdominal pain, rashes appeared on the lower limbs a few days later, they were subsequently diagnosed with IgA V. Both patients were given IV methylprednisolone, achieved benign clinical results.ConclusionsWhen gastrointestinal symptoms precede the rashes, it is difficult to diagnose IgA vasculitis, resulting in unnecessary surgery. Early recognition and treatment will promote the remission of the children and avoid unnecessary surgery.

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Section: Casementioning

confidence: 97%

“…Moreover, IBD patients developed IgA vasculitis after being treated with adalimumab [16]. There are also 2 literature reports that 3 cases of children with Crohn's disease were diagnosed with IgA vasculitis [4,12 ] . Another study showed that the incidence of IgA nephritis in IBD patients was signi cantly higher than that in non-IBD patients.…”

Section: Casementioning

confidence: 99%

IgA vasculitis with terminal ileitis and giant duodenum ulceration and review of the literatures

Wang

2021

Preprint

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“…Known HSP triggers include infection, medications, and allergic reactions. In children, anti‐TNF therapy has recently been published as a potential trigger of HSP 4 . However, there are no widely known associations between HSP and underlying disease.…”

Section: Introductionmentioning

confidence: 99%

Henoch Schonlein purpura in pediatric patients with inflammatory bowel disease: A case series

Sheth

Vivar

Wagner

et al. 2021

Pediatric Dermatology

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Henoch Schonlein purpura (HSP) is a small vessel vasculitis involving IgA immune complex deposition. HSP is characterized by nonthrombocytopenic palpable purpura, arthritis, abdominal pain, and glomerulonephritis. Mean onset of HSP is 6 years, with most cases occurring in children under 10. 1 HSP is often self-limited, generally resolving with supportive treatment in 1-2 months, though patients with renal involvement can have urinary abnormalities for months to years. 2,3 Recurrence of HSP occurs in 33%-35% of patients, generally within four months of the first episode. [1][2][3] Recurrences are typically shorter and milder than the original episode and may be more common in patients with HSP nephritis. 3 Known HSP triggers include infection, medications, and allergic reactions. In children, anti-TNF therapy has recently been published as a potential trigger of HSP. 4 However, there are no widely known associations between HSP and underlying disease. In adults, associations between HSP and liver cirrhosis as well as malignancy have been reported. 5,6 This case series reviews the clinical course of HSP in five patients with IBD.

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Infliximab/methotrexate

2022

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Henoch-Schönlein purpura and crohn’s disease: Expanding the range of association in pediatric patients

Cited by 5 publications

References 10 publications

IgA vasculitis with terminal ileitis and giant duodenum ulceration and review of the literatures

IgA vasculitis with terminal ileitis and giant duodenum ulceration and review of the literatures

Henoch Schonlein purpura in pediatric patients with inflammatory bowel disease: A case series

Infliximab/methotrexate

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