Hemostatic mechanisms of a soluble fraction of plant-derived sodium carboxymethyl cellulose

Aoshima, Motonori; Tanabe, Koji; Kohno, Isao; Jo, Yoshio; Takahashi, Kei; Sugo, Teruko; Matsuda, Michio

doi:10.2491/jjsth.23.387

Cited by 16 publications

(15 citation statements)

References 13 publications

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“…It was revealed that while dissolved CMC did not affect the onset of clotting (clotting time) significantly, it increased the mechanical strength of clots immediately after the onset, meaning that a dense fibrin network was formed in the presence of CMC. These results are consistent with those reported in previous studies by Aoshima et al (19). They reported that thick fibrin fibers were formed in the CMC-containing blood.…”

Section: Discussionsupporting

confidence: 94%

“…Some groups have reported that CMC dissolved in blood can promote blood clotting (19e21). For example, Aoshima et al recently showed that dissolved CMC worked as a "bridge" for fibrin polymerization, leading to thick fibrin fiber formation and thus improving blood clotting (19). Activation of platelet coagulation by dissolved CMC was also reported by Wang et al (20).…”

mentioning

confidence: 83%

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Development of carboxymethyl cellulose nonwoven sheet as a novel hemostatic agent

Ohta

Nishiyama

Sakoda

et al. 2015

Journal of Bioscience and Bioengineering

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Section: Discussionsupporting

confidence: 94%

mentioning

confidence: 83%

Development of carboxymethyl cellulose nonwoven sheet as a novel hemostatic agent

Ohta

Nishiyama

Sakoda

et al. 2015

Journal of Bioscience and Bioengineering

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“…Carboxyl groups were dissociated by the influence of sodium salts and the free particles could react with components of the blood. It was reported also that carboxymethyl cellulose interacts with fibrin to stabilize the clot [22]. Previously published studies revealed the effect of etamsylate only in specific situations and the exact mechanics of its action remains unclear [41].…”

Section: Discussionmentioning

confidence: 99%

“…It is applied primarily as a wound-healing dressing or as an implantable material. Upon closer examination, the hemostatic potential has also been revealed [21,22]. So far, composite materials utilizing hyaluronic acid and carboxymethyl cellulose have been developed as a barrier against undesired adhesion in surgery [23].…”

Section: Introductionmentioning

confidence: 99%

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

et al. 2020

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The achievement of rapid hemostasis represents a long-term trend in hemostatic research. Specifically, composite materials are now the focus of attention, based on the given issues and required properties. In urology, different materials are used to achieve fast and effective hemostasis. Additionally, it is desirable to exert a positive influence on local tissue reaction. In this study, three nonwoven textiles prepared by a wet spinning method and based on a combination of hyaluronic acid with either oxidized cellulose or carboxymethyl cellulose, along with the addition of etamsylate, were introduced and assessed in vivo using the rat partial nephrectomy model. A significantly shorter time to hemostasis in seconds (p < 0.05), was attributed to the effect of the carboxymethyl cellulose material. The addition of etamsylate did not noticeably contribute to further hemostasis, but its application strengthened the structure and therefore significantly improved the effect on local changes, while also facilitating any manipulation by the surgeons. Specifically, the hyaluronic acid supported the tissue healing and regeneration, and ensured the favorable results of the histological analysis. Moreover, the prepared textiles proved their bioresorbability after a three-day period. In brief, the fabrics yielded favorable hemostatic activity, bioresorbability, non-irritability, and had a beneficial effect on the tissue repair.

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“…SCM-PC induces the formation of the fibrin fibers, which activate plasminogen and cause the plasminogen activator to bind to the fibrin. This increases aggregation of the fibrin monomers, by means of the two-stranded fibrin protofibril formation [ 59 ]. Apart from this oxidized regenerated cellulose (ORC), due to the presence of the fibers within it, ORC serves as a platform for an aggregation of the platelets [ 60 ].…”

Section: Characteristics Of Pc and Bcmentioning

confidence: 99%

Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review

Naomi

Idrus

Fauzi

2020

IJERPH

105

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Cellulose is a naturally existing element in the plant’s cell wall and in several bacteria. The unique characteristics of bacterial cellulose (BC), such as non-toxicity, biodegradability, hydrophilicity, and biocompatibility, together with the modifiable form of nanocellulose, or the integration with nanoparticles, such as nanosilver (AgNP), all for antibacterial effects, contributes to the extensive usage of BC in wound healing applications. Due to this, BC has gained much demand and attention for therapeutical usage over time, especially in the pharmaceutical industry when compared to plant cellulose (PC). This paper reviews the progress of related research based on in vitro, in vivo, and clinical trials, including the overall information concerning BC and PC production and its mechanisms in wound healing. The physicochemical differences between BC and PC have been clearly summarized in a comparison table. Meanwhile, the latest Food and Drug Administration (FDA) approved BC products in the biomedical field are thoroughly discussed with their applications. The paper concludes on the need for further investigations of BC in the future, in an attempt to make BC an essential wound dressing that has the ability to be marketable in the global marketplace.

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Hemostatic mechanisms of a soluble fraction of plant-derived sodium carboxymethyl cellulose

Cited by 16 publications

References 13 publications

Development of carboxymethyl cellulose nonwoven sheet as a novel hemostatic agent

Development of carboxymethyl cellulose nonwoven sheet as a novel hemostatic agent

Composite Hemostatic Nonwoven Textiles Based on Hyaluronic Acid, Cellulose, and Etamsylate

Plant- vs. Bacterial-Derived Cellulose for Wound Healing: A Review

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