Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury

Li, Yunlong; Li, Hui; Xiao, Liping; Zhou, Lin; Shentu, Jianzhong; Zhang, Xumin; Fan, Jie

doi:10.3390/ma5122586

Cited by 31 publications

(30 citation statements)

References 23 publications

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“…In the literature, there are numerous studies, which report temperature rise, and serious necrosis of tissue at the bleeding site due to exothermic reaction caused by alumina‐silicate‐based hemostatic agents . The data justified the obtained results.…”

Section: Resultssupporting

confidence: 60%

Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model

Karahaliloğlu

Demirbilek

Ulusoy

et al. 2016

J of Applied Polymer Sci

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Recently, an effective hemostatic dressing requirement has become a major problem in both the military and civilian world. Available hemostatic agents are too expensive, ineffective, unsafe, or complicated to use. Here, we evaluated the hemostatic efficacy of a nano/micro bilayer hemostatic dressing including a porous sublayer from chitosan (CTS) and bacterial cellulose (BC) and a nanofibrillar upper layer from silk fibroin (SF). In addition, several active agents rolled in coagulation cascade [vitamin K (Vit K), protamine sulfate (PS), kaolin (Kao), etc.] were doped to the sublayer of bilayer hemostatic agent and their activities were compared via in vivo and in vitro tests. Lactate dehydrogenase (LDH) activity test results demonstrated that BC/CTS, SF-coated BC/CTS, and Vit K K/BC/CTS, SF/phosphatidylcholine (PC)-coated BC/CTS showed higher LDH activity compared to standard gauze (p < 0.005). In a femoral artery bleeding rat model, SF-coated PS/BC/CTS significantly reduced bleeding time (80 6 0.3 s) compared to standard gauze and kaolin-doped group (p < 0.005). Blood loss and mortality rate with 2.3 g and 37.5% SF-coated BC/CTS and SF-coated PS/BC/CTS showed increased efficacy in achieving hemostasis compared to standard gauze. All the prepared hemostatic dressings except for kaolin-doped BC/CTS and standard gauze induced no inflammatory reaction in the tissue. All these data suggest that active agent-doped BC/CTS/SF-based bilayer hemostatic dressings have a great influence on the resulting hemostatic action. V C 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016, 133, 43657.

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Section: Resultssupporting

confidence: 60%

Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model

Karahaliloğlu

Demirbilek

Ulusoy

et al. 2016

J of Applied Polymer Sci

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“…Similarly, vascular leakage may also be prevented by this mechanical effect (29).It has been shown that wound healing is accelerated by clinoptilolite, due to its effects on cytokines. After the injury, cytokines activate complement formation, platelet aggregation, blood coagulation and hemostasis, as well as release of growth factors, neovascularization, granulation tissue formation, and finally wound healing occurs(30).…”

mentioning

confidence: 99%

Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Aksoy¹,

Tunk²,

Sevinç³

et al. 2019

Deu Med J

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Objective: Seroma formation is one of the most frequent complications following breast cancer surgery. Although many techniques and drugs have been investigated, no definitive data are available concerning how to prevent this complication. The present study aims to investigate impact of local clinoptilolite application on seroma formation in an experimental mastectomy model created in rats. Material and Method: Two groups with seven rats in each were randomised. Under general anesthesia, all rats underwent right mastectomy and axillary dissection. Clinoptilolite was locally applied to surgical sites in the study group, whereas no application was performed in the control group. Ten days after the surgery, seroma formation was evaluated and tissue samples were obtained from the surgical sites, for both biochemical and histopathological examination Results: There was statistically significant decrease in seroma formation after clinoptilolite application (p=0.002). In addition, granulation tissue formation was significantly higher in the study group (p=0.006). No statistical difference was found between groups in terms of biochemical parameters. Conclusion: The reducing effect of seroma formation by clinoptilolite application may be due to its crystal cage structure. It collects seroma with its sero-absorbent features and creates granuloma formation that reduces dead-space, therefore accelarating wound healing.

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“…However, the interaction of this zeolite material with blood (aqueous medium) is substantially exothermic, resulting in sudden rise in local temperature, which was found to cause tissue damage and debilitation . In this aspect some research is being directed toward modulating the composition and structure of these zeolite minerals to retain its hemostatic property while reducing the exothermic side effects . In recent years, Quikclot has been used to modify the matrix of standard gauze and sponge used in US military, resulting in a technology named Quikclot combat gauze (QCG) or Quikclot‐advanced clotting sponge that is considered to reduce the exothermic side effect of the mineral because of coabsorption by the gauze .…”

Section: Hemostatic Biomaterials and Technologies For Topical (Externmentioning

confidence: 99%

Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding

et al. 2017

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Bleeding complications arising from trauma, surgery, and as congenital, disease-associated, or drug-induced blood disorders can cause significant morbidities and mortalities in civilian and military populations. Therefore, stoppage of bleeding (hemostasis) is of paramount clinical significance in prophylactic, surgical, and emergency scenarios. For externally accessible injuries, a variety of natural and synthetic biomaterials have undergone robust research, leading to hemostatic technologies including glues, bandages, tamponades, tourniquets, dressings, and procoagulant powders. In contrast, treatment of internal noncompressible hemorrhage still heavily depends on transfusion of whole blood or blood's hemostatic components (platelets, fibrinogen, and coagulation factors). Transfusion of platelets poses significant challenges of limited availability, high cost, contamination risks, short shelf-life, low portability, performance variability, and immunological side effects, while use of fibrinogen or coagulation factors provides only partial mechanisms for hemostasis. With such considerations, significant interdisciplinary research endeavors have been focused on developing materials and technologies that can be manufactured conveniently, sterilized to minimize contamination and enhance shelf-life, and administered intravenously to mimic, leverage, and amplify physiological hemostatic mechanisms. Here, a comprehensive review regarding the various topical, intracavitary, and intravenous hemostatic technologies in terms of materials, mechanisms, and state-of-art is provided, and challenges and opportunities to help advancement of the field are discussed.

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Hemostatic Efficiency and Wound Healing Properties of Natural Zeolite Granules in a Lethal Rabbit Model of Complex Groin Injury

Cited by 31 publications

References 23 publications

Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model

Hemostatic activities of nano/microporous bilayer dressings in a femoral artery bleeding rat model

Effects of locally applied Clinoptilolite (Froximun®) on seroma formation in a rat mastectomy and axillary lymph node dissection model

Biomaterials and Advanced Technologies for Hemostatic Management of Bleeding

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