Hemostatic Effects of a Novel Estradiol-Based Oral Contraceptive

Abstract

Background: A novel estradiol-based combined oral contraceptive (COC) is currently available in many countries worldwide, including Europe and the US. Based on previous studies, it is expected that this estradiol-based COC will have a reduced hepatic effect compared with COCs containing ethinylestradiol with regard to proteins controlling the hemostatic balance. Objective: The aim of this study was to compare the hemostatic effects of the estradiol valerate/dienogest COC with a monophasic low-estrogen dose COC containing ethinylestradiol/levonorgestrel. Study Design: Healthy women aged 18-50 years were randomized to receive a COC containing estradiol valerate/dienogest (2 days estradiol valerate 3 mg, 5 days estradiol valerate 2 mg/dienogest 2 mg, 17 days estradiol valerate 2 mg/dienogest 3 mg, 2 days estradiol valerate 1 mg, 2 days placebo) or ethinylestradiol 0.03 mg/levonorgestrel 0.15 mg in a crossover study design. Women received each treatment for three cycles, with two washout cycles between treatments. The primary efficacy variables were the intra-individual absolute changes in prothrombin fragment 1 + 2 and D-dimer from baseline to cycle three. Results: Data from 29 women were assessed. Intra-individual absolute changes in prothrombin fragment 1 + 2 and D-dimer from baseline to cycle three were less pronounced with estradiol valerate/dienogest than with ethinylestradiol/ levonorgestrel. Conclusion: The novel COC containing estradiol valerate/dienogest had similar or less pronounced effects on hemostatic parameters than ethinylestradiol/levonorgestrel.

Effect of Oral Contraceptive Pills on Levels of Calcium and Vitamin D in women in Al-Najaf Province

“…The results display no significant effect (p< 0.05) on calcium level in serum in the women at different age groups (20-25y ,26-31y and 32-38y) after intake oral contraceptive pill in compared with control group at different age groups (20-25y ,26-31y and 32-38y) respectively figure (1) and results also display no significant effect (p< 0.05) on calcium level in serum in the women between groups of ages.…”

“…Combined oral contraceptive pills commonly refer to pills in which an oestrogen and a progestogen are given parallel in a monthly cycle. Combined oral contraceptives (COCs) consume become a prevalent method of birth control because to their contraceptive effectiveness and good tolerability profile [1]. Combined oral contraceptives are so typically administered as a pill containing oestrogen and progestogen, which is taken daily for 20-22 days, followed by a seven-day pill-free interval (or seven days of placebo), during which time a withdrawal bleed is expected to happen.…”

The influence of oral combined oral contraceptive with estradiol valerate and dienogest on hemostatic system (a review)

“…рый отражает степень чувствительности исследуемой плазмы к активированному протеину С) [1][2][3][9][10][11].…”

“…В рандомизированном исследовании C. Klipping и соавт. [3] сравнивалось влияние на гемостаз ЭВ/ диеногеста и ЭЭ/левоноргестрела. Результаты этого исследования показывают, что препарат, содержащий ЭВ/диеногест, имеет аналогичное или меньшее влияние на гемостаз по сравнению с монофазными КОК, содержащими ЭЭ/левоноргестрел.…”

“…Индекс АРСрезистентности остался неизменным в обеих группах, в то время как средний коэффициент чувствительности АРС показал статистически значимое увеличение в группе ЭЭ/левоноргестрел. Однако, несмотря на отсутствие значимых различий между группами по большинству параметров в 3-м цикле приема препаратов, количество женщин со значениями выше референсных показателей было выше в группе ЭЭ/левоноргестрел [3].…”