Hemostatic dressings based on poly(vinyl formal) sponges

Goncharuk, Olena; Korotych, Olena; Samchenko, Yu. M.; Kernosenko, L.; Кравченко, А. Р.; Shtanova, L. Ya.; Tsуmbalуuk, O.; Poltoratska, Tetiana; Пасмурцева, Н.; Mamyshev, Igor E.; Pakhlov, E.M.; Siryk, Olena

doi:10.1016/j.msec.2021.112363

Cited by 19 publications

(9 citation statements)

References 35 publications

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“…Sponges have been extensively used for various biomedical applications, including tissue engineering [47] and drug delivery [48] due to their excellent properties such as porous structure, ease in fabrication, ability to absorb massive amounts of biological fluids or water, capability to act as natural tissue physical properties, and remarkable biocompatibility. Recently, sponges of natural or synthetic biomaterials such as polyvinyl alcohol, gelatin, and chitosan have emerged as attractive hemostatic materials due to their soft physical structure, high absorption capacity, large-scale production, and easily applicable to the bleeding site [49][50][51][52]. Among them, the chitosan-based sponge materials have been widely investigated for hemostatic applications due to their unique features, including no genetic toxicity, no cytotoxicity, no hemolysis, excellent biological compatibility, and biodegradable properties [53,54].…”

Section: Sf Sponge/filmmentioning

confidence: 99%

Silk Fibroin-Based Biomaterials for Hemostatic Applications

et al. 2022

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Hemostasis plays an essential role in all surgical procedures. Uncontrolled hemorrhage is the primary cause of death during surgeries, and effective blood loss control can significantly reduce mortality. For modern surgeons to select the right agent at the right time, they must understand the mechanisms of action, the effectiveness, and the possible adverse effects of each agent. Over the past decade, various hemostatic agents have grown intensely. These agents vary from absorbable topical hemostats, including collagen, gelatins, microfibrillar, and regenerated oxidized cellulose, to biologically active topical hemostats such as thrombin, biological adhesives, and other combined agents. Commercially available products have since expanded to include topical hemostats, surgical sealants, and adhesives. Silk is a natural protein consisting of fibroin and sericin. Silk fibroin (SF), derived from silkworm Bombyx mori, is a fibrous protein that has been used mostly in fashion textiles and surgical sutures. Additionally, SF has been widely applied as a potential biomaterial in several biomedical and biotechnological fields. Furthermore, SF has been employed as a hemostatic agent in several studies. In this review, we summarize the several morphologic forms of SF and the latest technological advances on the use of SF-based hemostatic agents.

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Section: Sf Sponge/filmmentioning

confidence: 99%

Silk Fibroin-Based Biomaterials for Hemostatic Applications

et al. 2022

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“…It might be caused by some synergy and highly functional interactions between them, where the CMC creates the hydrogel structure, seals the wound and allows the collagen to actively interact with clotting factors and blood proteins and enhances the hemostasis. Hemostatic tests in rats were also conducted by Goncharuk et al 2021 when they tested polyvinyl formal sponges on rats' livers, they didn't measure the time needed for achieving hemostasis, but they measured blood loss. Zheng et al, 2023 tested W-HAP-PVA aerogel (composed of ultralong hydroxyapatite nanowires and poly(vinyl alcohol)) on rats' liver, and in rabbit femoral artery injury and when compared, our wound dressings can achieve faster hemostasis time.…”

Section: Discussionmentioning

confidence: 99%

A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings

Sedlář

Kacvinská

Fohlerová

et al. 2023

Preprint

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Bleeding is one of the most commonly occurring injuries; it can be painful and even life-threatening condition. The hemostats are substances that promote blood clotting and fasten hemostasis. In this paper, we evaluated the hemostatic effect of freeze-dried wound dressings based on equine collagen, porcine collagen, fibrous carboxymethyl cellulose (CMC) and their mixtures. The wound dressings were investigated for their morphological structure, chemical structure, absorption properties, in vitro hemostasis, cytotoxicity assay and lastly, for in vivo hemostasis. We have found out that adding fibrous CMC into collagen-based hemostatic wound dressings creates a strong synergistic effect, which significantly improves absorption capacity by almost doubling it, as well as supports clotting time. Based on the in vivo studies on partial nephrectomy in rats, the time needed for achieving hemostasis was significantly lower due to the synergy of collagen and CMC. Our materials were compared to the commonly used hemostatic sealing patch on the market (Tachosil) during the in vivo testing, and sample of a mixture of equine collagen and CMC showed better hemostatic efficacy.

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“…Typically, the addition of starch and other poreforming agents or surfactants is required to create pores in the sponge. 28 Starch is the most commonly used pore-forming agent, and its mechanism can be briefly described as follows: starch is uniformly dispersed in the system, and simultaneous with the initiation of the acetalization reaction, starch particles absorb water, gradually increasing in size and swelling to the maximum; facilitated by the catalyst, glycosidic bonds in starch undergo hydrolysis and breakage; ultimately, after the completion of the acetalization reaction and starch hydrolysis, the through-hole PVF sponge material is obtained. Zhang et al 30 successfully prepared a PVF sponge with an average pore size of 150 μm by using starch as a pore-forming agent.…”

Section: Introductionmentioning

confidence: 99%

Tailored Pore Size and Hydrophilicity: Advancing Poly(vinyl formal) Sponges for Efficient Emulsion Separation

Zhang,

Dai,

Hui

et al. 2024

ACS Appl. Polym. Mater.

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In the field of emulsion separation, the application of porous hydrophilic sponge materials is of paramount importance; however, the conventional preparation process of hydrophilic poly(vinyl formal) (PVF) restricts the simultaneous enhancement of separation efficiency and water flux. In this work, by introducing two poly(vinyl alcohol) (PVA) and aldehyde feedstocks with different molecular weights and functional group contents into the reaction system, the differences in the mobility and reactivity of the feedstocks were exploited to successfully achieve tailoring of the pore size and hydrophilicity. The PVF sponge prepared by using this method exhibited high separation efficiency and water flux in emulsion separation. This preparation method not only avoided the requirement for pore-forming agents in traditional preparations but also significantly reduced the amount of formaldehyde by adding trace amounts of glutaraldehyde, ensuring the hydrophilicity of the sponge and markedly reducing the pore size. The experimental results showed that the addition of 1.5 × 10 −3 mol/L glutaraldehyde could effectively reduce the average pore size of the PVF sponge from 26.5 to 7.2 μm while maintaining excellent hydrophilicity. The preparation mechanism of PVF sponges was thoroughly explored, and the effects of different concentrations of formaldehyde and glutaraldehyde on the sponge properties were extensively investigated. Experimental results demonstrated that the prepared PVF sponge achieved a separation efficiency of up to 98.5% for the OP-10-stabilized oil-inwater emulsion and exhibited outstanding recyclability. This cost-effective and easily scalable method for PVF sponge preparation could be employed to produce a range of highly efficient filtration materials, effectively separating target oil-in-water emulsions.

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Hemostatic dressings based on poly(vinyl formal) sponges

Cited by 19 publications

References 35 publications

Silk Fibroin-Based Biomaterials for Hemostatic Applications

Silk Fibroin-Based Biomaterials for Hemostatic Applications

A synergistic effect of fibrous carboxymethyl cellulose with equine collagen improved the hemostatic properties of freeze-dried wound dressings

Tailored Pore Size and Hydrophilicity: Advancing Poly(vinyl formal) Sponges for Efficient Emulsion Separation

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