Abstract:of Philadelphia, reported observations on a familial hemorrhagic disorder affecting only males but transmissable via some of the unaffected females. Otto's observations undoubtedly concerned patients whom we now speak of as having hemophilia A (classical hemophilia, antihemophilic factor [AHF] deficiency) or hemophilia B (Christmas disease,2 plasma thromboplastin component [PTC] deficiency3), the genetics of these two disorders being apparently identical.Thus the term "sex-linked recessive" has been applied t… Show more
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