Hemostatic Comparison of a Polysaccharide Powder and a Gelatin Powder

Abstract

Characterization of tissue explant ultrastructure, particle size, and swelling revealed differences in the materials. BGP, in addition to absorbing fluid and concentrating clotting factors and platelets, integrate into the clot and stabilize the fibrin matrix. BGP have advantages over MPH in terms of speed and efficacy. BGP are a favorable biomaterial for further research that greatly improve the limited efficacy of powdered hemostats.

Hemostatic materials in non-variceal upper gastrointestinal hemorrhage

“…Park et al 10 by propensity score matching, compared to the conventional endoscopic methods, found that there were no significant differences from the immediate hemostasis success rate of the 30 patients treated with EndoClot nor the incidence of rebleeding rate after 7 and 30 days. 11,12 However, Singh et al 13 conducted a study of hemostatic materials showing that the hemostatic success of commercially available microporous polysaccharide hemispheres was much lower than that of bovine-derived gelatin particles.…”

Use of hemostatic agents for surgical bleeding in laparoscopic partial nephrectomy: Biomaterials perspective

“…Its performance was compared with FloSeal® in a porcine hepatic abrasion model and better bleeding control and significantly less blood loss was achieved with FloSeal® (Lewis et al, 2015). Most recently, a similar study was conducted, which was earlier mentioned in this review (Singh et al, 2018). This work aimed at comparing the hemostatic performance of BGP with ARISTA™ AH and, similarly to the former study, the results indicated that hemostasis can be attained quicker and more efficiently with BGP.…”

“…In addition, the authors emphasized the easy application of FloSeal® through the laparoscopic port and its effectiveness even when applied in wet surfaces (Figure 3; Ozgor et al, 2016). Recently, the hemostatic powder of bovine‐derived gelatin particles (BGP) was evaluated in comparison with a commercial HA composed of microporous polysaccharide hemospheres (MPH), ARISTA™ AH (Singh et al, 2018). The study was conducted in pig models where lesions in the liver were created and then treated with HAs.…”

“…The results showed a better hemostatic response for BGP over ARISTA™ AH. BGP induced the platelet activation and provides a tamponade effect in the bleeding site, allowing a faster and more efficient performance (Singh et al, 2018). HAs based on gelatin are widely used with success in LPN; however, a comprehensive study of the tumor case should always be performed to evaluate the suitability of these products (Gazzeri et al, 2018).…”

An Efficacy Comparison of Two Hemostatic Agents in a Porcine Liver Bleeding Model: Gelatin/Thrombin Flowable Matrix versus Collagen/Thrombin Powder

“…Powdered hemostatic agents have been developed for use in surgical procedures. These agents are typically mechanical in nature, with examples including polysaccharide-, mineral-, and gelatinbased powders which can create a barrier layer at the bleeding site [7][8][9]. In comparison with flowable agents, powdered hemostatic agents can be directly applied without reconstitution and can cover large surface areas when the exact site of bleeding is not known; however, their efficacy has been limited to low-level bleeds.…”