Hemostatic activity of the polymer ferakril

Hemostatic polymers: the concept, state of the art and perspectives

“…In the early 1980s, Russian scientists developed Feracryl®, a poly(acrylic acid) (12) containing up to 2.5% of iron(III) salt coordinated to it. 58,59 The material showed good hemostatic properties, which the authors ascribed to the formation of "articial" clots consisting of Feracryl®/plasma proteins adducts. 58,60 Since the hemostatic activity and the polymer solubility were found to be dependent on the iron content, the authors surmised that the latter might have an active role in the adduct formation.…”

“…58,59 The material showed good hemostatic properties, which the authors ascribed to the formation of "articial" clots consisting of Feracryl®/plasma proteins adducts. 58,60 Since the hemostatic activity and the polymer solubility were found to be dependent on the iron content, the authors surmised that the latter might have an active role in the adduct formation. 61 However, poly(acrylic acid) being highly hygroscopic, one cannot exclude that the absorption of water from blood with the subsequent concentration of coagulation factors and platelets at the bleeding site might play a role in the overall antihemorrhagic effect.…”

“…58,60 Since the hemostatic activity and the polymer solubility were found to be dependent on the iron content, the authors surmised that the latter might have an active role in the adduct formation. 61 However, poly(acrylic acid) being highly hygroscopic, one cannot exclude that the absorption of water from blood with the subsequent concentration of coagulation factors and platelets at the bleeding site might play a role in the overall antihemorrhagic effect. In vivo experiments demonstrated that Feracryl® is nontoxic when applied locally and also did not cause any complications when used externally as well as on internal organs during surgery.…”

Antibacterial and antifungal activity of feracryl

“…

Feracryl is a hemostatic drug of local action [1,2] licensed for the practical application.Because feracryl can be used under conditions favorable to the development of wound infection, it was of interest to study the antibacterial and antifungal properties of the drug.

EXPERIMENTAL PARTThe bacteriostatic and mycostatic activity of feracryl with respect to 11 strains of microorganisms was determined by the method of serial dilutions. We have studied Experiments were performed on 18-h broth incubated cultures of streptococcus and staphylococcus (meat-extract broth supplemented with 10% normal horse seruna), 18-h agar cultures (Hottinger broth) of the other bacteria, and 3 -5-day broth incubated cultures of microsporon (Sabouraud's medium).

…”