Hemostatic Abnormality and Associated Factors in Diabetic Patients at Jimma University Specialized Hospital, Jimma, Southwest Ethiopia: A Comparative Cross-sectional Study

Asrat, Debebe; Tesfaye, Girum; Gedefaw, Lealem; Addisu, Wondimagegn; Yemane, Tilahun

doi:10.4314/ejhs.v29i2.12

Cited by 6 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A comparative cross-sectional study conducted in a different part of the world also revealed that there is a shortening of PT and aPTT values among T2DM patients. This study finding is supported by different studies conducted by Ankalayya et al in India, 45 Mariappan et al in India, 46 Karim et al in Bangladesh, 47 Ephraim et al in Ghana, 37 Pan et al in China, 48 Sapkota et al in Nepal, 49 Asrat et al in Ethiopia, 40 and Ambelu et al in Ethiopia, 24 which showed that T2DM patients were presented with significant shortening of PT and aPTT.…”

Section: Discussionsupporting

confidence: 79%

“… 44 In addition to this, studies that are conducted in different parts of the world supported the presence of thrombocytopenia among T2DM patients. A comparative cross-sectional study conducted by Pan et al in China, 48 Madan et al in India, 55 and Asrat et al in Ethiopia 40 showed that T2DM patients were presented with thrombocytopenia.…”

Section: Discussionmentioning

confidence: 97%

“… 37 The prevalence of coagulopathy in this study is lower compared to a study conducted by Asrat et al in Ethiopia, which reported a 58.8% prevalence of coagulopathy in the diabetes population (Both type I & II). 40 The possible reasons for these disagreements might be associated with differences in the study population, coagulation parameters studied, the reference range used for the CBC and coagulation tests, the difference in sample size, and the study design used.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Getu¹,

Aynalem²,

Bizuneh³

et al. 2022

DMSO

View full text Add to dashboard Cite

Introduction Diabetes mellitus is a heterogeneous disorder of metabolism which results hyperglycemic-related atherothrombotic complications. These complications are the leading cause of death in diabetes mellitus patients. Therefore, this study was aimed to determine the prevalence of coagulopathy and associated factors among adult type II diabetes mellitus patients attending at University of Gondar comprehensive specialized hospital. Methods A facility-based cross-sectional study was conducted among 357 study participants. A questionnaire and a data collection sheet were used to collect the sociodemographic and clinical data, respectively. About 6mL of venous blood samples were collected for coagulation tests and complete blood count. For prolonged coagulation tests, a mixing test was performed. Data were entered into EpiInfo and exported to SPSS for statistical analysis. Then, descriptive statistics were done. A binary and multivariable logistic regression model was used to identify the associated factors. P-value <0.05 was considered as statistically significant. Results In this study, 357 study participants were included. Of them, 52.1% (186) and 80.7% (288) were females and urban residences, respectively. The prevalence of coagulopathy was 26.6% (95% CI: 22.1, 31.5%). Out of this, 12.3% and 8.7% showed shortened PT and aPTT, respectively. In addition, the prevalence of prolonged PT and aPTT were 5.6% and 3.9%, respectively. From the prolonged PT and aPTT, the prevalence of factor deficiency was 95% and 92.8%, respectively. Being female (AOR = 2.06; 95% CI: 1.11–3.85%), abnormal BMI (AOR = 1.94; 95% CI: 1.08–3.50), and educational status of high school (AOR = 0.26; 95% CI: 0.10–0.83%) were significantly associated with hypercoagulation. Conclusion Coagulopathy is an important public health problem among type II diabetes mellitus patients. Being female and having abnormal BMI were associated with hypercoagulation. Therefore, regular monitoring of coagulation parameters is vital to reduce the consequence of coagulopathy.

show abstract

Section: Discussionsupporting

confidence: 79%

Section: Discussionmentioning

confidence: 97%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

Getu¹,

Aynalem²,

Bizuneh³

et al. 2022

DMSO

View full text Add to dashboard Cite

show abstract

“…In the present study, protein C and S activity was significantly lower in the diabetic rats than in the controls. It is thought that these proteins undergo structural changes caused by non-enzymatic glycation, which results in dysfunction [37]. However, in the present study, these deficiencies in plasma protein C and S in diabetic rats were significantly reversed after they received sildenafil.…”

Section: Resultscontrasting

confidence: 71%

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Hussein¹

2022

Pharmacophore

View full text Add to dashboard Cite

Sildenafil citrate (SC) is a phosphodiesterase type-5 inhibitor, which acts to increase cyclic guanosine monophosphate (cGMP). This study aims to assess the effects of Sildenafil citrate (SC) on glycemic control and hematological parameters of diabetic rats induced with streptozotocin (STZ). Fifty male Wistar rats were divided into four groups (n=10/non-diabetic group; n=15/diabetic group): i. control (I), ii. SC-treated control (II), iii. diabetic (III), and iv. SC-treated diabetic (IV). Diabetes was induced by an intraperitoneal injection of STZ (50 mg/kg). SC (20 mg/kg body weight) was administered orally for six weeks. Blood specimens were taken to measure levels of serum glucose (FBG), insulin, glycated hemoglobin (HbA1c), aspartate aminotransferase (AST), alanine aminotransferase (ALT), urea, creatinine, prothrombin time (PT), partial thromboplastin time (aPTT), fibrinogen, protein C, and protein S. Levels of FBG, HbA1c, AST, ALT, urea, creatinine, and fibrinogen were significantly elevated in the rats with diabetes compared to the controls. Conversely, insulin, aPTT, protein C and S were significantly lower in the diabetic groups. No significant difference was seen in the PT of control and diabetic rats. No effect was found in the administration of SC on healthy control rats. Upon administration of SC to the diabetic rats, these parameters returned to normal (P<0.05). SC was found to improve glycemic control as well as microcirculatory perfusions in diabetic rats, warranting its consideration as a way to lessen diabetic complications.

show abstract

“…Higher glycemic levels in the hypocoagulable group might monitoring of acute conditions. 11,[16][17][18][19] Therefore, TEG might be less sensitive and less specific in detecting hemostasis abnormalities in subjects without acute critical comorbidities. Although several studies indicated significant associations between acute and chronic hyperglycemia with hemostasis abnormalities, those associations were not consistently found in all parameters of hemostasis and all subsets of T2DM patients.…”

Section: Normocoagulablementioning

confidence: 99%

Detection of Hemostasis Abnormalities in Type 2 Diabetes Mellitus Using Thromboelastography

Arsana

Firani

Fatonah

et al. 2022

JAFES

View full text Add to dashboard Cite

Introduction. Type 2 DM (T2DM) is associated with inflammation and vascular dysfunction which impact hemostasis. Thromboelastography (TEG) as a hemostasis assessment method, is not routinely applied in T2DM. We aimed to detect hemostasis abnormalities by using the TEG method in association with glycemic levels and type of therapy among T2DM patients.Methodology. A cross-sectional study was conducted among T2DM patients attending the Endocrinology Clinic of Saiful Anwar Hospital, Indonesia. Glycemic profiles were determined using fasting plasma glucose (FPG), 2-hour postprandial plasma glucose (2hPPG), and glycosylated hemoglobin (HbA1c). Therapy for T2DM was classified into insulin and noninsulin regimens. The primary and secondary hemostasis profile were examined using TEG and was classified as hypohyper-and normo-coagulable states.Result. A total of 57 T2DM patients were included. Kruskal-Wallis test did not reveal a significant association between glycemic profiles and groups of hemostasis. However, the median HbA1c was higher in the hypercoagulable group of primary hemostasis and fibrinolysis. The median FPG and 2hPPG were higher in the normo-coagulable group of secondary hemostasis. Logistic regression did not indicate a significant association between type of therapy for diabetes and hemostasis profile.Conclusion. This study did not find significant associations between glycemic levels and type of DM therapy with hemostasis profiles using the TEG method in patients with T2DM.

show abstract

Hemostatic Abnormality and Associated Factors in Diabetic Patients at Jimma University Specialized Hospital, Jimma, Southwest Ethiopia: A Comparative Cross-sectional Study

Cited by 6 publications

References 13 publications

The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

The Prevalence of Coagulopathy and Associated Factors Among Adult Type II Diabetes Mellitus Patients Attending the University of Gondar Comprehensive Specialized Hospital, Northwest Ethiopia

The Potential Effect of Sildenafil Citrate on Some Hematological and Biochemical Parameters in Hyperglycemic Rats

Detection of Hemostasis Abnormalities in Type 2 Diabetes Mellitus Using Thromboelastography

Contact Info

Product

Resources

About