Hemostatic abnormalities in patients with pulmonary embolism compared with that in deep vein thrombosis

Yamada, Norikazu; Wada, Hideo; Nakase, Taizen; Minamikawa, Kouzou; Nagaya, Satomi; Nakamura, Masio; Hiraoka, Naoto; Fuzioka, H.; Hayashi, Tokio; Suzuki, Kota; Nakano, Takeshi; Shiku, Hiroshi

doi:10.1097/00001721-199510000-00002

Cited by 31 publications

(24 citation statements)

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“…The overlooked patient had chronic PE and he had small size thrombus. However, as the hemostatic abnormalities are more significant in DVT patients with PE than those without PE [21], the difference between patients with PE and without PE was not significant in this study. This is probably because our study was too small and the PE was not severe.…”

Section: Discussioncontrasting

confidence: 67%

“…SF and D-dimer are considered as markers of hypercoagulable state, as both parameters are reported to be elevated in DVT [3,21], DIC [22,23], and hyperlipidemia [24]. In the present study, plasma concentrations of D-dimer and SF were significantly high in patients with DVT, but those levels were also significantly high in patients without DVT.…”

Section: Discussionsupporting

confidence: 50%

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Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer

et al. 2005

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The present study was designed to determine the cutoff values of D-dimer and soluble fibrin (SF) for the diagnosis of deep venous thrombosis (DVT) and pulmonary embolism (PE) in Japanese patients. Plasma levels of these molecules were measured in 243 patients suspected of having DVT and 100 healthy volunteers (controls). Out of 243 patients, 20 patients were diagnosed with DVT. In the control group, plasma levels of D-dimer and SF did not show normal distribution, and the 95% confidence intervals (CI) of D-dimer and SF were 2.45 mg/mL and 6.92 mg/mL, respectively. Plasma levels of D-dimer and SF of patients with DVT were significantly higher than of those without DVT. In patients with DVT, the minimum values of D-dimer and SF were 1.71 and 1.44 mg/mL, respectively. When the cutoff value was set at the average + 1 SD of those of the control (D-dimer, about 1.8 mg/ mL; SF, about 1.4 mg/mL), 1 and 0 patient with DVT was overlooked, respectively. The sensitivity and specificity of D-dimer and SF for DVT were 95% and 100%, and 61.9% and 53.8%, respectively. When the cutoff value was set at 95% CI of the control (D-dimer, 2.5 mg/ mL; SF, 6.9 mg/mL), 2 and 9 patients with DVT were overlooked, respectively. The sensitivity and specificity of D-dimer and SF were 90% and 50%, and 77.6% and 88.3%, respectively. When the cutoff values set at 2.5 mg/mL of D-dimer or 6.9 mg/mL of SF, 1 DVT patient was overlooked, with sensitivity and specificity of 95% and 69.5%. Our data suggest that both D-dimer and SF are useful markers for the diagnosis of DVT and that measurement of both D-dimer and SF increases the sensitivity and specificity for the diagnosis of DVT/PE.

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Section: Discussioncontrasting

confidence: 67%

Section: Discussionsupporting

confidence: 50%

Diagnosis of deep vein thrombosis by plasma-soluble fibrin or D-dimer

et al. 2005

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“…Meanwhile, the levels of FDP and D-dimer were significantly high in the patients with various types of malignant diseases, suggesting that elevated FDP and Ddimer levels are caused by both thrombotic states and malignant diseases. Elevated levels of FRMs, such as D-dimer and SF, are also observed in patients under a hypercoagulable state (25), such as those with DVT (26,27), DIC (28) or hyperlipidemia (29). Therefore, it is important to determine the adequate cut-off values of FRMs for diagnosing thrombosis in patients with malignant diseases.…”

Section: Discussionmentioning

confidence: 99%

Elevated Fibrin-related Markers in Patients with Malignant Diseases Frequently Associated with Disseminated Intravascular Coagulation and Venous Thromboembolism

et al. 2014

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“…To our knowledge, Takano et al [10] reported for the first time that plasma sTM level was increased in patients with PTE. Then several papers reported similar findings in PTE patients in succession [28,29]. In contrast, Aleksic et al [30] did not find significant difference in plasma sTM levels between PTE patients and controls in the LITE Study.…”

Section: Discussionmentioning

confidence: 83%