Hemostatic Ability of Chitosan‐Phosphate Inspired by Coagulation Mechanisms of Platelet Polyphosphates

Wang, Younseon; Kim, Keumyeon; Lee, Moon Sue; Lee, Haeshin

doi:10.1002/mabi.201700378

Cited by 34 publications

(16 citation statements)

References 32 publications

(31 reference statements)

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“…A mouse-hemorrhaging liver model was used for controlling hemostasis studies. , The mouse (Kunming mice, weight of 40–50 g, female) was anesthetized prior to surgery. After abdominal incision, the mouse liver was carefully exposed, and a preweighed filter paper on a paraffin film was placed beneath the liver.…”

Section: Methodsmentioning

confidence: 99%

Injectable and Sprayable Polyphenol-Based Hydrogels for Controlling Hemostasis

Geng

Dai

Sun

et al. 2020

ACS Appl. Bio Mater.

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Injectable and sprayable hydrogels have attracted considerable attention for application in the biomedical field owing to their high moldability and efficiency in encapsulating therapeutics and cells. Herein, we report the spontaneous assembly of injectable and sprayable hydrogels via a one-step mixing of solutions of tannic acid (TA) and O-carboxymethyl chitosan (CMCS) without an external stimulus. The presence of 1,4-benzenediboronic acid (BDBA) improves the mechanical properties and reduces the gelation time of the resulting hydrogels. The hydrogels assemble via hydrogen bonds between TA and CMCS as well as via dynamic boronate ester bonds between TA and BDBA, as confirmed by Fourier transform infrared spectroscopy. Balancing the interactions between the three components (CMCS/TA/BDBA) is essential for the construction of the hydrogels. The moduli of the CMCS–TA–BDBA hydrogels initially increase as the amount of BDBA increases and decrease after reaching a maximum value at a BDBA-to-TA molar ratio of 3:1. The CMCS–TA–BDBA hydrogels with interconnected porous morphologies display rapid gelation (∼10 s), biocompatibility, self-healing, injectable, and sprayable abilities. In addition, the hydrogels can be used for hemostasis. The extent of bleeding in mouse livers treated with the hydrogels could be reduced extensively from 240 (nontreated mouse livers) to 55 mg (77% reduction). The reported hydrogels coupled with the combination of functionality and biological activity make them promising hemostatic materials for biomedical applications.

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Section: Methodsmentioning

confidence: 99%

Injectable and Sprayable Polyphenol-Based Hydrogels for Controlling Hemostasis

Geng

Dai

Sun

et al. 2020

ACS Appl. Bio Mater.

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“…Drugs to reduce capillary permeability: (1) phenolsulfonethylamine (hemostatic) works by promoting the process of coagulation. Can increase platelet aggregation and adhesion in the blood, promote the release of clotting substances, in order to accelerate blood coagulation [149]. Clinically, it is used to prevent and treat bleeding caused by surgical bleeding, thrombocytopenic purpura or Henoch-Schonlein purpura and other causes.…”

Section: Discussionmentioning

confidence: 99%

Hemostatic Effect and Safety of TXA: An Umbrella Review

Jiang

Deng

Liu

et al. 2020

Preprint

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Aim To evaluate the hemostatic effect and safety of tranexamic acid (TXA). Methods Meta-analyses were retrieved from databases. Risk ratios (RR), odds ratios (OR), weighted mean difference (WMD), standard mean difference (SMD) and 95% confidence intervals (CI) were extracted to compare the effeteness of TXA in reducing TBL, transfusion rate, Hb drop, mortality, DVT, PE. Results In total, 136 trials (396 comparisons) including 17 kinds of surgeries were retrieved. The evidence for TXA using in total knee arthroplasty (TKA), total hip arthroplasty (THA), postpartum bleeding, intertrochanteric fractures, orthopaedic surgery, spinal surgery, shoulder arthroplasty, hip fracture surgery, cardiac surgery, menstrual bleeding, plastic surgery, myomectomy, nasal surgery was assessed as possible for the association of reducing TBL. The evidence for TXA using in TKA, THA, postpartum bleeding, orthopaedic surgery, shoulder arthroplasty was assessed as probable for the association of reducing transfusion rate. The evidence for TXA using in liver surgery, spinal surgery, hip fracture surgery, cancer, cardiac surgery was considered to be possible for the association of reducing transfusion rate. The evidence for TXA using in intertrochanteric fractures, orthopaedic surgery, hip fracture surgery was assessed as probable for the association of reducing Hb drop. The evidence for TXA using in TKA, THA, postpartum bleeding, shoulder arthroplasty was considered to be possible for the association of reducing Hb drop. The evidence for TXA using in trauma, gastrointestinal bleeding was assessed as probable for the association of reducing mortality. Conclusion This umbrella review indicated that TXA were regarded as effective to reduce TBL, transfusion rate, Hb drop, mortality, and did not increase the incidence of DVT and PE. However, more convincing evidence should be provided to further clarify the level of efficacy and safety of TXA.

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“…The mouse (normal SD mouse, 160–180 g) hemorrhaging liver model was adopted to examine the hemostatic properties of hydrogels. , In brief, the mouse was paralyzed with 5 wt % chloral hydrate and immobilized on the plastic base. After an abdominal incision, the serous fluid around the liver was carefully removed and the liver was exposed.…”

Section: Methodsmentioning

confidence: 99%

Polysaccharide-Based Adhesive Antibacterial and Self-Healing Hydrogel for Sealing Hemostasis

et al. 2022

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Adhesive hydrogels have been considered as one of the most ideal materials for wound dressing. However, most existing adhesive hydrogels still have disadvantages such as low mechanical properties, poor biological activity (antibacterial and hemostatic ability), and low biocompatibility, which largely limit their application. Thus, it is highly desired to prepare a hydrogel-based wound dressing with good self-healing, ideal adhesive properties, rapid hemostasis, and excellent wound infection prevention activity. In this study, a simple method was presented to prepare a PAM-Lignin-CS-Laponite-SA hydrogel for wound dressing. The obtained hydrogel displayed excellent self-healing ability and repeatable adhesive performance, benefiting from the introduction of hydrogen bonding and electrostatic interactions inside the hydrogel network. In addition, the PAM-Lignin-CS-Laponite-SA hydrogel also exhibited low cell cytotoxicity, good antibacterial activity, and outstanding hemostatic properties. In conclusion, the PAM-Lignin-CS-Laponite-SA hydrogel demonstrated good tissue adhesion, excellent self-healing ability, effective bleeding control, and good antibacterial activity to prevent wound infection, which provides a new idea for developing a multifunctional hydrogel-based tissue adhesive hemostatic dressing.

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Hemostatic Ability of Chitosan‐Phosphate Inspired by Coagulation Mechanisms of Platelet Polyphosphates

Cited by 34 publications

References 32 publications

Injectable and Sprayable Polyphenol-Based Hydrogels for Controlling Hemostasis

Injectable and Sprayable Polyphenol-Based Hydrogels for Controlling Hemostasis

Hemostatic Effect and Safety of TXA: An Umbrella Review

Polysaccharide-Based Adhesive Antibacterial and Self-Healing Hydrogel for Sealing Hemostasis

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