Hemostasis in Xenotransplantation

Improved Hepatic Microcirculation by Human Soluble Urinary Thrombomodulin in the Xeno-Perfused Porcine Liver

“…These changes in the reperfused liver might contribute to the hypercoagulability status, disturbance in hepatic microcirculation, and massive liver necrosis, resulting in an early graft failure (18). The hypercoagulability status in the reperfused liver might become more evident in xenogeneic perfusion of the porcine liver, in which marked fibrin deposition on the porcine endothelium overwhelmed other findings of weak deposition of antibody deposition and complement deposition (19). The hypercoagulability status in the reperfused liver might become more evident in xenogeneic perfusion of the porcine liver, in which marked fibrin deposition on the porcine endothelium overwhelmed other findings of weak deposition of antibody deposition and complement deposition (19).…”