Hemostasis and Neuroscience—Hemostasis and Fibrinolysis Involved in Brain Pathology and Brain Disorders

Hvas, Christine Lodberg; Kwaan, Hau C.; Hvas, Anne‐Mette

doi:10.1055/s-0042-1742737

Cited by 3 publications

(3 citation statements)

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“…(ii) A hemorrhagic stroke is caused by bleeding in or around the brain due to ruptured blood vessels. Efficient control of the coagulation and fibrinolytic systems in brain tissues is thus clearly important in diminishing the potential impact of stroke and the promotion of functional recovery of brain function (Hvas et al., 2022; Medcalf, 2017). Thrombin has key roles to play in the coagulation pathway.…”

Section: Serine Proteases and Mmps In Neural Development And Neurodeg...mentioning

confidence: 99%

CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity

Melrose

2024

J of Neuroscience Research

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Central and peripheral nervous system (CNS/PNS) proteoglycans (PGs) have diverse functional roles, this study examined how these control cellular behavior and tissue function. The CNS/PNS extracellular matrix (ECM) is a dynamic, responsive, highly interactive, space‐filling, cell supportive, stabilizing structure maintaining tissue compartments, ionic microenvironments, and microgradients that regulate neuronal activity and maintain the neuron in an optimal ionic microenvironment. The CNS/PNS contains a high glycosaminoglycan content (60% hyaluronan, HA) and a diverse range of stabilizing PGs. Immobilization of HA in brain tissues by HA interactive hyalectan PGs preserves tissue hydration and neuronal activity, a paucity of HA in brain tissues results in a pro‐convulsant epileptic phenotype. Diverse CS, KS, and HSPGs stabilize the blood–brain barrier and neurovascular unit, provide smart gel neurotransmitter neuron vesicle storage and delivery, organize the neuromuscular junction basement membrane, and provide motor neuron synaptic plasticity, and photoreceptor and neuron synaptic functions. PG‐HA networks maintain ionic fluxes and microgradients and tissue compartments that contribute to membrane polarization dynamics essential to neuronal activation and neurotransduction. Hyalectans form neuroprotective perineuronal nets contributing to synaptic plasticity, memory, and cognitive learning. Sialoglycoprotein associated with cones and rods (SPACRCAN), an HA binding CSPG, stabilizes the inter‐photoreceptor ECM. HSPGs pikachurin and eyes shut stabilize the photoreceptor synapse aiding in phototransduction and neurotransduction with retinal bipolar neurons crucial to visual acuity. This is achieved through Laminin G motifs in pikachurin, eyes shut, and neurexins that interact with the dystroglycan–cytoskeleton–ECM‐stabilizing synaptic interconnections, neuronal interactive specificity, and co‐ordination of regulatory action potentials in neural networks.

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Section: Serine Proteases and Mmps In Neural Development And Neurodeg...mentioning

confidence: 99%

CNS/PNS proteoglycans functionalize neuronal and astrocyte niche microenvironments optimizing cellular activity by preserving membrane polarization dynamics, ionic microenvironments, ion fluxes, neuronal activation, and network neurotransductive capacity

Melrose

2024

J of Neuroscience Research

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“…Some examples over recent years are shown in Table 2 . 17 18 19 20 21 22 23 24 25 26 Of course, since online activity has overtaken print usage, the collation of highly specific themes perhaps becomes less imperative, and so STH now also collates issues with broader themes around thrombosis, 27 28 29 and laboratory diagnostics and bleeding, 30 31 32 33 34 35 as well as material related to COVID-19 (coronavirus disease 2019). 36 37 38…”

Section: Tablementioning

confidence: 99%

“…Another point of difference is that STH has in the past tended to solely publish "themed" issues, with each issue being related to a separate topic within the field of thrombosis and hemostasis. Some examples over recent years are shown in ►Table 2 [17][18][19][20][21][22][24][25][26]…”

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confidence: 99%